Elena Ivleva, M.D., Ph.D.

Peter O'Donnell Jr. Brain Institute

Psychiatry

Biography

Elena Ivleva, M.D., Ph.D., is an Associate Professor in the Department of Psychiatry’s Division of Translational Neuroscience Research in Schizophrenia at UT Southwestern Medical Center. She serves as the department’s Director of the Early Psychosis Clinical and Research Program. She specializes in the treatment of schizophrenia and related psychotic disorders.

Dr. Ivleva earned her medical degree and her doctoral degree in neuroscience at Voronezh State Medical Academy in Russia. She completed a residency in psychiatry at Voronezh State Medical Academy, followed by a postdoctoral fellowship conducting neurobiological research in schizophrenia at UT Southwestern, where she also performed a research-track residency in psychiatry.

Certified by the American Board of Psychiatry and Neurology, Dr. Ivleva joined the UT Southwestern faculty in 2012.

In addition to her clinical practice, Dr. Ivleva is a dedicated physician-scientist in the field of neurobiological psychosis research. Her investigations are focused on understanding neurobiological mechanisms of schizophrenia and related disorders and developing human in vivo biomarkers for psychotic disorders, primarily using cognition and multimodal brain imaging measures.

Dr. Ivleva has delivered scores of presentations at national and international conferences, contributed to several psychiatry textbooks (including Kaplan & Sadock’s Comprehensive Textbook of Psychiatry and Neurobiology of Mental Illness), and published more than 50 academic articles. She is a recipient of research awards and funding from the National Institute of Mental Health, the Brain & Behavior Research Foundation, the American Psychiatric Association, and the Texas Health and Human Services Commission.

She is a member of the Society for Neuroscience, the Schizophrenia International Research Society, the American Psychiatric Association, the Early Intervention in Mental Health Society, and the Texas Society of Psychiatric Physicians, among other professional organizations.

Education & Training

Medical School - Voronezh State Medical Academy (1992-1998)
Residency - Voronezh State Medical Academy (1998-2000), Psychiatry
Graduate School - Voronezh State Medical Academy (1998-2001), Neuroscience
Residency - UT Southwestern Medical Center (2008-2012), Psychiatry
Other Post Graduate Training - Voronezh State Medical Academy (1998-2001)
Postdoctoral Fellowship - UT Southwestern Medical Center (2004-2008), Neurobiology of Psychotic Disorders

Books & Publications

Publications
- Impact of polygenic risk for coronary artery disease and cardiovascular medication burden on cognitive impairment in psychotic disorders.
  Zhang L, Hill SK, Guo B, Wu B, Alliey-Rodriguez N, Eum S, Lizano P, Ivleva EI, Reilly JL, Keefe RSE, Keedy SK, Tamminga CA, Pearlson GD, Clementz BA, Keshavan MS, Gershon ES, Sweeney JA, Bishop JR, Progress in neuro-psychopharmacology & biological psychiatry 2021 Oct 113 110464
- Subtyping Schizophrenia Patients Based on Patterns of Structural Brain Alterations.
  Xiao Y, Liao W, Long Z, Tao B, Zhao Q, Luo C, Tamminga CA, Keshavan MS, Pearlson GD, Clementz BA, Gershon ES, Ivleva EI, Keedy SK, Biswal BB, Mechelli A, Lencer R, Sweeney JA, Lui S, Gong Q, Schizophrenia bulletin 2021 Sep
- Auditory Oddball Responses Across the Schizophrenia-Bipolar Spectrum and Their Relationship to Cognitive and Clinical Features.
  Parker DA, Trotti RL, McDowell JE, Keedy SK, Hill SK, Gershon ES, Ivleva EI, Pearlson GD, Keshavan MS, Tamminga CA, Clementz BA, The American journal of psychiatry 2021 Aug appiajp202120071043
- Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.
  Clementz BA, Parker DA, Trotti RL, McDowell JE, Keedy SK, Keshavan MS, Pearlson GD, Gershon ES, Ivleva EI, Huang LY, Hill SK, Sweeney JA, Thomas O, Hudgens-Haney M, Gibbons RD, Tamminga CA, Schizophrenia bulletin 2021 Aug
- Multivariate Association of Child Depression and Anxiety with Asthma Outcomes.
  Kulikova A, Lopez J, Antony A, Khan DA, Persaud D, Tiro J, Ivleva EI, Nakamura A, Patel Z, Tipton S, Lloyd T, Allen K, Kaur S, Owitz MS, Pak RJ, Adragna MS, Chankalal R, Humayun Q, Lehman HK, Miller BD, Wood BL, Brown ES, The journal of allergy and clinical immunology. In practice 2021 Jun 9 6 2399-2405
- Genome-wide association study accounting for anticholinergic burden to examine cognitive dysfunction in psychotic disorders.
  Eum S, Hill SK, Alliey-Rodriguez N, Stevenson JM, Rubin LH, Lee AM, Mills LJ, Reilly JL, Lencer R, Keedy SK, Ivleva E, Keefe RSE, Pearlson GD, Clementz BA, Tamminga CA, Keshavan MS, Gershon ES, Sweeney JA, Bishop JR, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2021 Jun
- Biomarker Profiles in Psychosis Risk Groups Within Unaffected Relatives Based on Familiality and Age.
  Türközer HB, Ivleva EI, Palka J, Clementz BA, Shafee R, Pearlson GD, Sweeney JA, Keshavan MS, Gershon ES, Tamminga CA, Schizophrenia bulletin 2021 Mar
- Biotyping in psychosis: using multiple computational approaches with one data set.
  Tamminga CA, Clementz BA, Pearlson G, Keshavan M, Gershon ES, Ivleva EI, McDowell J, Meda SA, Keedy S, Calhoun VD, Lizano P, Bishop JR, Hudgens-Haney M, Alliey-Rodriguez N, Asif H, Gibbons R, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2021 Jan 46 1 143-155
- A randomized, double-blind, placebo-controlled proof-of-concept study of ondansetron for bipolar and related disorders and alcohol use disorder.
  Sherwood Brown E, McArdle M, Palka J, Bice C, Ivleva E, Nakamura A, McNutt M, Patel Z, Holmes T, Tipton S, European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2021 Jan
- No connectivity alterations for striatum, default mode, or salience network in association with self-reported antipsychotic medication dose in a large chronic patient group.
  Herms EN, Bishop JR, Okuneye VT, Tamminga CA, Keshavan MS, Pearlson GD, Clementz BA, McDowell JE, Ivleva EI, Gershon ES, Sweeney JA, Keedy SK, Schizophrenia research 2020 Sep 223 359-360
- Distinguishing patterns of impairment on inhibitory control and general cognitive ability among bipolar with and without psychosis, schizophrenia, and schizoaffective disorder.
  Gotra MY, Hill SK, Gershon ES, Tamminga CA, Ivleva EI, Pearlson GD, Keshavan MS, Clementz BA, McDowell JE, Buckley PF, Sweeney JA, Keedy SK, Schizophrenia research 2020 Sep 223 148-157
- Testing Psychosis Phenotypes From Bipolar-Schizophrenia Network for Intermediate Phenotypes for Clinical Application: Biotype Characteristics and Targets.
  Clementz BA, Trotti RL, Pearlson GD, Keshavan MS, Gershon ES, Keedy SK, Ivleva EI, McDowell JE, Tamminga CA, Biological psychiatry. Cognitive neuroscience and neuroimaging 2020 Aug 5 8 808-818
- Altered cerebral perfusion in bipolar disorder: A pCASL MRI study.
  Zeng V, Lizano P, Bolo NR, Lutz O, Brady R, Ivleva EI, Dai W, Clementz B, Tamminga C, Pearlson G, Keshavan M, Bipolar disorders 2020 Jun
- Imaging-Based Subtyping for Psychiatric Syndromes.
  Ivleva EI, Turkozer HB, Sweeney JA, Neuroimaging clinics of North America 2020 Feb 30 1 35-44
- Cognitive Impairment and Diminished Neural Responses Constitute a Biomarker Signature of Negative Symptoms in Psychosis.
  Hudgens-Haney ME, Clementz BA, Ivleva EI, Keshavan MS, Pearlson GD, Gershon ES, Keedy SK, Sweeney JA, Gaudoux F, Bunouf P, Canolle B, Tonner F, Gatti-McArthur S, Tamminga CA, Schizophrenia bulletin 2020 Feb
- NMDA receptor antibody seropositivity in psychosis: A pilot study from the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP).
  Blackburn KM, Ivleva EI, Weir RA, Kim M, Hopkins SC, Hudgens-Haney ME, Keedy SK, Gershon ES, Sweeney JA, Keshavan MS, Pearlson GD, Clementz BA, Tamminga CA, Vernino S, Schizophrenia research 2020 Jan
- Resting state auditory-language cortex connectivity is associated with hallucinations in clinical and biological subtypes of psychotic disorders.
  Okuneye VT, Meda S, Pearlson GD, Clementz BA, Keshavan MS, Tamminga CA, Ivleva E, Sweeney JA, Gershon ES, Keedy SK, NeuroImage. Clinical 2020 27 102358
- Brain gray matter network organization in psychotic disorders.
  Zhang W, Lei D, Keedy SK, Ivleva EI, Eum S, Yao L, Tamminga CA, Clementz BA, Keshavan MS, Pearlson GD, Gershon ES, Bishop JR, Gong Q, Lui S, Sweeney JA, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2019 Dec
- Relationship of prolonged acoustic startle latency to diagnosis and biotype in the bipolar-schizophrenia network on intermediate phenotypes (B-SNIP) cohort.
  Massa N, Owens AV, Harmon W, Bhattacharya A, Ivleva EI, Keedy S, Sweeney JA, Pearlson GD, Keshavan MS, Tamminga CA, Clementz BA, Duncan E, Schizophrenia research 2019 Nov
- The Relationship Between Cumulative Exogenous Corticosteroid Exposure and Volumes of Hippocampal Subfields and Surrounding Structures.
  Nguyen DM, Yassa MA, Tustison NJ, Roberts JM, Kulikova A, Nakamura A, Ivleva EI, Van Enkevort E, Brown ES, Journal of clinical psychopharmacology 2019 Nov/Dec 39 6 653-657
- NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis.
  Alliey-Rodriguez N, Grey TA, Shafee R, Asif H, Lutz O, Bolo NR, Padmanabhan J, Tandon N, Klinger M, Reis K, Spring J, Coppes L, Zeng V, Hegde RR, Hoang DT, Bannai D, Nawaz U, Henson P, Liu S, Gage D, McCarroll S, Bishop JR, Hill S, Reilly JL, Lencer R, Clementz BA, Buckley P, Glahn DC, Meda SA, Narayanan B, Pearlson G, Keshavan MS, Ivleva EI, Tamminga C, Sweeney JA, Curtis D, Badner JA, Keedy S, Rapoport J, Liu C, Gershon ES, Translational psychiatry 2019 Sep 9 1 230
- A randomized trial of an NMDA receptor antagonist for reversing corticosteroid effects on the human hippocampus.
  Brown ES, Kulikova A, Van Enkevort E, Nakamura A, Ivleva EI, Tustison NJ, Roberts J, Yassa MA, Choi C, Frol A, Khan DA, Vazquez M, Holmes T, Malone K, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2019 Jun
- Auditory steady-state EEG response across the schizo-bipolar spectrum.
  Parker DA, Hamm JP, McDowell JE, Keedy SK, Gershon ES, Ivleva EI, Pearlson GD, Keshavan MS, Tamminga CA, Sweeney JA, Clementz BA, Schizophrenia research 2019 May
- Transdiagnostic dimensions of psychosis in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP).
  Reininghaus U, Böhnke JR, Chavez-Baldini U, Gibbons R, Ivleva E, Clementz BA, Pearlson GD, Keshavan MS, Sweeney JA, Tamminga CA World psychiatry : official journal of the World Psychiatric Association (WPA) 2019 Feb 18 1 67-76
- A Randomized, Double-Blind, Placebo-Controlled Trial of Citicoline in Patients with Alcohol Use Disorder.
  Brown ES, Van Enkevort E, Kulikova A, Escalante C, Nakamura A, Ivleva EI, Holmes T Alcoholism, clinical and experimental research 2019 Feb 43 2 317-323
- A pilot study of brexpiprazole for bipolar depression.
  Brown ES, Khaleghi N, Van Enkevort E, Ivleva E, Nakamura A, Holmes T, Mason BL, Escalante C Journal of affective disorders 2019 Feb 249 315-318
- A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus.
  Brown ES, Sayed N, Choi C, Tustison N, Roberts J, Yassa MA, Van Enkevort E, Nakamura A, Ivleva EI, Sunderajan P, Khan DA, Vazquez M, McEwen B, Kulikova A, Frol AB, Holmes T European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2019 Jan
- Using Brain-Based Phenotyping to Improve Discovery in Psychiatry.
  Tamminga CA, Ivleva EI JAMA psychiatry 2018 Oct
- Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers.
  Mason BL, Ivleva EI, Van Enkevort E, Nakamura A, Brown ES Dementia and geriatric cognitive disorders 2018 Oct 46 3-4 186-192
- Molecular design, synthesis and biological evaluation of cage compound-based inhibitors of hepatitis C virus p7 ion channels.
  Shiryaev VA, Radchenko EV, Palyulin VA, Zefirov NS, Bormotov NI, Serova OA, Shishkina LN, Baimuratov MR, Bormasheva KM, Gruzd YA, Ivleva EA, Leonova MV, Lukashenko AV, Osipov DV, Osyanin VA, Reznikov AN, Shadrikova VA, Sibiryakova AE, Tkachenko IM, Klimochkin YN European journal of medicinal chemistry 2018 Aug 158 214-235
- Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers.
  Clementz BA, Sweeney JA, Hamm JP, Ivleva EI, Ethridge LE, Pearlson GD, Keshavan MS, Tamminga CA, Focus (American Psychiatric Publishing) 2018 Apr 16 2 225-236
- Associations between adolescent cannabis use and brain structure in psychosis.
  Abush H, Ghose S, Van Enkevort EA, Clementz BA, Pearlson GD, Sweeney JA, Keshavan MS, Tamminga CA, Ivleva EI Psychiatry research 2018 Mar
- Role of Matrix Metalloproteinase-2 in the Development of Cyclophosphamide-Induced Cardiomyopathy.
  Koldysheva EV, Klinnikova MG, Nikityuk DB, Ivleva EK, Listvyagova NA, Lushnikova EL Bulletin of experimental biology and medicine 2018 Mar 164 4 483-487
- A Randomized, Double-Blind, Placebo-Controlled Trial of Escitalopram in Patients with Asthma and Major Depressive Disorder.
  Brown ES, Sayed N, Van Enkevort E, Kulikova A, Nakamura A, Khan DA, Ivleva EI, Sunderajan P, Bender BG, Holmes T The journal of allergy and clinical immunology. In practice 2018 Feb
- Genetic analysis of deep phenotyping projects in common disorders.
  Gershon ES, Pearlson G, Keshavan MS, Tamminga C, Clementz B, Buckley PF, Alliey-Rodriguez N, Liu C, Sweeney JA, Keedy S, Meda SA, Tandon N, Shafee R, Bishop JR, Ivleva EI Schizophrenia research 2017 Oct
- Cognitive burden of anticholinergic medications in psychotic disorders.
  Eum S, Hill SK, Rubin LH, Carnahan RM, Reilly JL, Ivleva EI, Keedy SK, Tamminga CA, Pearlson GD, Clementz BA, Gershon ES, Keshavan MS, Keefe RS, Sweeney JA, Bishop JR Schizophrenia research 2017 Apr
- Identifying dynamic functional connectivity biomarkers using GIG-ICA: Application to schizophrenia, schizoaffective disorder, and psychotic bipolar disorder.
  Du Y, Pearlson GD, Lin D, Sui J, Chen J, Salman M, Tamminga CA, Ivleva EI, Sweeney JA, Keshavan MS, Clementz BA, Bustillo J, Calhoun VD Human brain mapping 2017 Mar
- Examining Functional Resting-State Connectivity in Psychosis and Its Subgroups in the Bipolar-Schizophrenia Network on Intermediate Phenotypes Cohort.
  Meda SA, Clementz BA, Sweeney JA, Keshavan MS, Tamminga CA, Ivleva EI, Pearlson GD Biological psychiatry. Cognitive neuroscience and neuroimaging 2016 Nov 1 6 488-497
- Brain Structure Biomarkers in the Psychosis Biotypes: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes.
  Ivleva EI, Clementz BA, Dutcher AM, Arnold SJ, Jeon-Slaughter H, Aslan S, Witte B, Poudyal G, Lu H, Meda SA, Pearlson GD, Sweeney JA, Keshavan MS, Tamminga CA Biological psychiatry 2016 Aug
- Cognitive Function in Individuals With Psychosis: Moderation by Adolescent Cannabis Use.
  Hanna RC, Shalvoy A, Cullum CM, Ivleva EI, Keshavan M, Pearlson G, Hill SK, Sweeney JA, Tamminga CA, Ghose S Schizophrenia bulletin 2016 Mar
- Commentary: Clinical Approach to the Differential Diagnosis between Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders.
  Jha MK, Ivleva E Frontiers in psychiatry 2016 7 23
- Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers.
  Clementz BA, Sweeney JA, Hamm JP, Ivleva EI, Ethridge LE, Pearlson GD, Keshavan MS, Tamminga CA The American journal of psychiatry 2015 Dec appiajp201514091200
- Alterations in hippocampal connectivity across the psychosis dimension.
  Samudra N, Ivleva EI, Hubbard NA, Rypma B, Sweeney JA, Clementz BA, Keshavan MS, Pearlson GD, Tamminga CA Psychiatry research 2015 Jun
- Frequency-Specific Neural Signatures of Spontaneous Low-Frequency Resting State Fluctuations in Psychosis: Evidence From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium.
  Meda SA, Wang Z, Ivleva EI, Poudyal G, Keshavan MS, Tamminga CA, Sweeney JA, Clementz BA, Schretlen DJ, Calhoun VD, Lui S, Damaraju E, Pearlson GD Schizophrenia bulletin 2015 May
- Loss of pattern separation performance in schizophrenia suggests dentate gyrus dysfunction.
  Das T, Ivleva EI, Wagner AD, Stark CE, Tamminga CA Schizophrenia research 2014 Oct 159 1 193-7
- Hippocampal Volume Is Reduced in Schizophrenia and Schizoaffective Disorder But Not in Psychotic Bipolar I Disorder Demonstrated by Both Manual Tracing and Automated Parcellation (FreeSurfer).
  Arnold SJ, Ivleva EI, Gopal TA, Reddy AP, Jeon-Slaughter H, Sacco CB, Francis AN, Tandon N, Bidesi AS, Witte B, Poudyal G, Pearlson GD, Sweeney JA, Clementz BA, Keshavan MS, Tamminga CA Schizophrenia bulletin 2014 Feb
- Gray Matter Volume as an Intermediate Phenotype for Psychosis: Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP).
  Ivleva EI, Bidesi AS, Keshavan MS, Pearlson GD, Meda SA, Dodig D, Moates AF, Lu H, Francis AN, Tandon N, Schretlen DJ, Sweeney JA, Clementz BA, Tamminga CA The American journal of psychiatry 2013 Nov 170 11 1285-96
- Clinical Phenotypes of Psychosis in the Bipolar and Schizophrenia Network on Intermediate Phenotypes (B-SNIP).
  Tamminga CA, Ivleva EI, Keshavan MS, Pearlson GD, Clementz BA, Witte B, Morris DW, Bishop J, Thaker GK, Sweeney JA The American journal of psychiatry 2013 Jul
- Smooth Pursuit Eye Movement, Prepulse Inhibition, and Auditory Paired Stimuli Processing Endophenotypes Across the Schizophrenia-Bipolar Disorder Psychosis Dimension.
  Ivleva EI, Moates AF, Hamm JP, Bernstein IH, O'Neill HB, Cole D, Clementz BA, Thaker GK, Tamminga CA Schizophrenia bulletin 2013 Apr
- Predictive pursuit association with deficits in working memory in psychosis.
  Moates AF, Ivleva EI, O'Neill HB, Krishna N, Cullum CM, Thaker GK, Tamminga CA Biological psychiatry 2012 Nov 72 9 752-7
- Brain gray matter phenotypes across the psychosis dimension.
  Ivleva EI, Bidesi AS, Thomas BP, Meda SA, Francis A, Moates AF, Witte B, Keshavan MS, Tamminga CA Psychiatry research 2012 Oct 204 1 13-24
- Memory generalization is selectively altered in the psychosis dimension.
  Ivleva EI, Shohamy D, Mihalakos P, Morris DW, Carmody T, Tamminga CA Schizophrenia research 2012 Jun 138 1 74-80
- Cognitive endophenotypes of psychosis within dimension and diagnosis.
  Ivleva EI, Morris DW, Osuji J, Moates AF, Carmody TJ, Thaker GK, Cullum M, Tamminga CA Psychiatry research 2012 Mar 196 1 38-44
- Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary.
  Ivleva EI, Morris DW, Moates AF, Suppes T, Thaker GK, Tamminga CA Neuroscience and biobehavioral reviews 2010 May 34 6 897-921
- Comparing genes and phenomenology in the major psychoses: schizophrenia and bipolar 1 disorder.
  Ivleva E, Thaker G, Tamminga CA Schizophrenia bulletin 2008 Jul 34 4 734-42
- Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims.
  Cui H, Nishiguchi N, Ivleva E, Yanagi M, Fukutake M, Nushida H, Ueno Y, Kitamura N, Maeda K, Shirakawa O Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008 Jun 33 7 1537-44
- Cognition in schizophrenia.
  Hyman SE, Ivleva E The American journal of psychiatry 2008 Mar 165 3 312
- Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study.
  Isohanni M, Miettunen J, Mäki P, Murray GK, Ridler K, Lauronen E, Moilanen K, Alaräisänen A, Haapea M, Isohanni I, Ivleva E, Tamminga C, McGrath J, Koponen H World psychiatry : official journal of the World Psychiatric Association (WPA) 2006 Oct 5 3 168-71