- Medical School - Johns Hopkins University (1985-1990)
- Internship - Greater Baltimore Medical Center (1990-1991), Internal Medicine
- Residency - Wills Eye Hospital (1991-1994), Ophthalmology
- Fellowship - Bascom Palmer Eye Institute (1994-1995), Retina
- Fellowship - University of California San Francisco (1995-1996), Ocular Oncology Pathology
- Research Fellowship - Washington University School of Medicine (1996-1999), Molecular Oncology
J. William Harbour, M.D.
- The David Bruton, Jr. Chair in Ophthalmology
- Ophthalmology
- Ocular oncology
- Retinoblastoma
Biography
J. William Harbour, M.D., is Professor and Chair of the Department of Ophthalmology at UT Southwestern Medical Center. He specializes in ocular oncology.
Dr. Harbour earned his medical degree at Johns Hopkins University and completed a residency in ophthalmology at the Wills Eye Hospital of Thomas Jefferson University. He received advanced training through a fellowship in vitreoretinal diseases and surgery at the Bascom Palmer Eye Institute of the University of Miami, a fellowship in ocular oncology at the University of California, San Francisco, and research training in molecular oncology at Washington University in St. Louis.
Certified by the American Board of Ophthalmology, he joined the UT Southwestern faculty in 2021.
Previously, Dr. Harbour held the Dr. Mark J. Daily, M.D., Endowed Chair at the Bascom Palmer Eye Institute, where he also served as Director of Ocular Oncology and Vice Chair for Translational Research. He also served as Associate Director for Basic Science at the Sylvester Comprehensive Cancer Center of the University of Miami.
Dr. Harbour’s clinical interests focus on ocular tumors such as uveal melanoma, retinoblastoma, and lymphoma. He has trained many residents and fellows and pioneered new surgical methods in fine needle biopsy, laser treatment, and brachytherapy of ocular tumors. He also has been awarded patents for innovations in genetic prognostic testing for uveal melanoma.
His research interests include the use of genetic and genomic technologies to better understand, diagnose, and treat eye cancers. His team discovered three of the most important genomic drivers of metastasis in uveal melanoma, as well as key genomic events in retinoblastoma. His contributions to the field have been recognized by the Association for Research in Vision and Ophthalmology’s Cogan Award and the Macula Society’s Paul Henkind and Rosenthal Awards, among many others.
Dr. Harbour has delivered more than 300 invited scientific lectures and published more than 200 peer-reviewed scientific articles and book chapters.
He is an Associate Editor for Melanoma Research and has served on the editorial boards of Archives of Ophthalmology, Translational Vision Science & Technology, Melanoma Management, Expert Review of Ophthalmology, and Faculty of 1000.
Dr. Harbour is a member of numerous professional organizations, including the Association of American Physicians, American Academy of Ophthalmology, American Association for Cancer Research, and American Association of Ophthalmic Oncologists and Pathologists, and he is the founder of the Collaborative Ocular Oncology Group.
Education & Training
Professional Associations & Affiliations
- American Academy of Ophthalmology
- American Association for Cancer Research
- American Association of Ophthalmic Oncologists and Pathologists
- American Ophthalmological Society
- American Society of Retina Specialists
- Association of American Physicians
- Association for Research in Vision and Ophthalmology
- Children’s Oncology Group
- Collaborative Ocular Oncology Group (Founder)
- International Society of Ocular Oncology
- J. Donald M. Gass Society
- Macula Society
- Retina Society
- Society of Heed Fellows
- Society for Melanoma Research
Honors & Awards
- Alcon Research Institute Award 2016
- Retina Research Foundation/Kayser Global Award 2015, Pan-American Association of Ophthalmology
- Silver Fellow 2014, Association for Research in Vision and Ophthalmology
- Senior Scientific Investigator 2014, Research to Prevent Blindness, Inc.
- Paul Henkind Memorial Award and Lecture 2014, Macula Society
- Honor Award 2013, American Society of Retina Specialists
- Shaler Richardson, MD Service to Medicine Award 2013, Florida Society of Ophthalmology
- Senior Achievement Award 2012, American Academy of Ophthalmology
- Research Award 2011, Ocular Melanoma Foundation
- Rosenthal Award 2008, Macula Society
- Cogan Award 2005, Association for Research in Vision and Ophthalmology
- Achievement Award 2003, American Academy of Ophthalmology
- Physician-Scientist Award 2002, Research to Prevent Blindness, Inc.
- Heed-Knapp Ophthalmic Fellowship 1995-1996, University of California, San Francisco
- Heed Ophthalmic Foundation Fellowship 1994-1995, Bascom Palmer Eye Institute
Books & Publications
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Publications
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PRAME induces genomic instability in uveal melanoma.
Harbour JW, Kurtenbach S, Sanchez M, Kuznetsoff J, Rodriguez D, Weich N, Dollar J, Cruz A, Kurtenbach S, Field M, Decatur C, Sorouri M, Lai F, Shiekhattar R, Pelaez D, Correa Z, Verdun R, Research square 2023 Apr -
Advances in the clinical management of uveal melanoma.
Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S, Nature reviews. Clinical oncology 2023 Feb 20 2 99-115 -
Pseudoangiomatous retinal gliosis (PARG) treated with iodine plaque in patient with chronic retinal detachment.
Marquez MA, Fortun J, Iyer P, Harbour JW, Haddock LJ, American journal of ophthalmology case reports 2022 Sep 27 101614 -
Clinical characteristics and postoperative complications as predictors of radiation toxicity after treatment with I125 Eye Plaque Brachytherapy for Uveal Melanomas.
Peters V, Gurayah A, Jin W, Kwon D, Zhao W, Patel NV, Markoe A, Correa Z, Studenski MT, Harbour JW, Samuels SE, Brachytherapy 2022 Sep -
RB1 loss triggers dependence on ESRRG in retinoblastoma.
Field MG, Kuznetsoff JN, Zhang MG, Dollar JJ, Durante MA, Sayegh Y, Decatur CL, Kurtenbach S, Pelaez D, Harbour JW, Science advances 2022 Aug 8 33 eabm8466 -
The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries.
The Lancet. Global health 2022 08 10 8 e1128-e1140 -
BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in Class 2 Uveal Melanomas.
Kaler CJ, Dollar JJ, Cruz AM, Kuznetsoff JN, Sanchez MI, Decatur CL, Licht JD, Smalley KSM, Correa ZM, Kurtenbach S, Harbour JW, Cancers 2022 Jul 14 15 -
Dissecting the Interplay Between Genetic Ancestry and Neighborhood Socioeconomic Status on Triple Negative Breast Cancer.
Goel N, Yadegarynia S, Kwon D, Kesmodel SB, Harbour JW, Kobetz E, Merchant N, Rodriguez DA, Annals of surgery 2022 Jun -
Hematologic Complications Associated With Intra-arterial Chemotherapy for Retinoblastoma Treatment: A Single Institution Experience.
Sanati-Mehrizy A, Ghosh T, Peterson E, Starke RM, Harbour JW, Corrales-Medina FF, Journal of pediatric hematology/oncology 2022 May 44 4 181-185 -
Multi-omics profiling shows BAP1 loss is associated with upregulated cell adhesion molecules in uveal melanoma.
Baqai U, Purwin TJ, Bechtel N, Chua V, Han A, Hartsough EJ, Kuznetsoff JN, Harbour JW, Aplin AE, Molecular cancer research : MCR 2022 Apr -
HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma.
Sriramareddy SN, Faião-Flores F, Emmons MF, Saha B, Chellappan S, Wyatt C, Smalley I, Licht JD, Durante MA, Harbour JW, Smalley KSM, Cancer gene therapy 2022 Mar -
Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma.
Han A, Chua V, Baqai U, Purwin TJ, Bechtel N, Hunter E, Tiago M, Seifert E, Speicher DW, Schug ZT, Harbour JW, Aplin AE, Oncogene 2022 Jan -
Analytical Validation and Performance of a 7-Gene Next-Generation Sequencing Panel in Uveal Melanoma.
Alsina KM, Sholl LM, Covington KR, Arnal SM, Durante MA, Decatur CL, Stone JF, Oelschlager KM, Harbour JW, Monzon FA, Cook RW, Borman S, Ocular oncology and pathology 2021 Dec 7 6 428-436 -
Functional impact of titin (TTN) mutations in ocular surface squamous neoplasia.
Djulbegovic MB, Uversky VN, Karp CL, Harbour JW, International journal of biological macromolecules 2021 Nov -
Structural Protein Analysis of Driver Gene Mutations in Conjunctival Melanoma.
Djulbegovic MB, Uversky VN, Harbour JW, Galor A, Karp CL, Genes 2021 Oct 12 10 -
Waking Up With Cloudy Vision.
Khine KT, Clark WM, Harbour JW, JAMA ophthalmology 2021 Oct -
Multiregional genetic evolution of metastatic uveal melanoma.
Rodriguez DA, Yang J, Durante MA, Shoushtari AN, Moschos SJ, Wrzeszczynski KO, Harbour JW, Carvajal RD, NPJ genomic medicine 2021 Aug 6 1 70 -
The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma.
Chua V, Han A, Bechtel N, Purwin TJ, Hunter E, Liao C, Harbour JW, Aplin AE, Pigment cell & melanoma research 2021 Aug -
Iris Mass in a 14-Month-Old Boy.
Ashkenazy N, Walter SD, Harbour JW, JAMA ophthalmology 2021 Jul 139 7 802-803 -
Secondary Glaucoma Associated with Intraocular Metastatic Cutaneous Melanoma.
Greenfield JA, Rowlands M, Harbour JW, Ophthalmology. Glaucoma 2021 Jul -
Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase.
Peng H, Cassel J, McCracken DS, Prokop JW, Sementino E, Cheung M, Collop PR, Polo A, Joshi S, Mandell JP, Ayyanathan K, Hinds D, Malkowicz SB, Harbour JW, Bowcock AM, Salvino J, Kennedy EJ, Testa JR, Rauscher FJ, Molecular cancer research : MCR 2021 07 19 7 1099-1112 -
Multiple genetically distinct uveal melanomas arise in the same eye of two patients with melanosis oculiUnilateral multifocal uveal melanoma in melanosis oculi.
Wagley S, Belin PJ, Dollar JJ, Harbour JW, Maltry AC, Mruthyunjaya P, Schefler AC, Tang PH, American journal of ophthalmology 2021 Jul -
Iris metastasis from breast cancer successfully treated with Abemaciclib and Letrozole.
Goduni L, Ashkenazy N, Hansen E, Soyano-Muller A, Correa ZM, Harbour JW, Retinal cases & brief reports 2021 Jun -
Therapeutic Escape in Gaq-mutant Uveal Melanoma: It's a FAK.
Harbour JW, Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Jun 27 11 2967-2969 -
Uphyloplot2: visualizing phylogenetic trees from single-cell RNA-seq data.
Kurtenbach S, Cruz AM, Rodriguez DA, Durante MA, Harbour JW, BMC genomics 2021 Jun 22 1 419 -
Comprehensive assessment of the effect of eye plaque tilt on tumor dosimetry.
Studenski MT, Markoe A, Samuels SE, Correa ZM, Bossart E, Harbour JW, Brachytherapy 2021 Jun -
Multimodal Imaging in the Diagnosis of Exophytic Juxtapapillary Retinal Capillary Hemangioblastoma.
Russell JF, Villegas VM, Schwartz SG, Weng CY, Davis JL, Flynn HW, Harbour JW, American journal of ophthalmology 2021 05 225 128-136 -
PieParty: visualizing cells from scRNA-seq data as pie charts.
Kurtenbach S, Dollar JJ, Cruz AM, Durante MA, Decatur CL, Harbour JW, Life science alliance 2021 05 4 5 -
Correction to: BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.
Han A, Purwin TJ, Bechtel N, Liao C, Chua V, Seifert E, Sato T, Schug ZT, Speicher DW, Harbour JW, Aplin AE, Oncogene 2021 Mar 40 9 1753 -
Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma.
Kuznetsoff JN, Owens DA, Lopez A, Rodriguez DA, Chee NT, Kurtenbach S, Bilbao D, Roberts ER, Volmar CH, Wahlestedt C, Brothers SP, Harbour JW, Molecular cancer research : MCR 2021 02 19 2 215-222 -
Chimerism involving a RB1 pathogenic variant in monochorionic dizygotic twins with twin-twin transfusion syndrome.
Armitage AM, Kundra MA, Ghiam N, Atwal PS, Morel D, Hruska KS, Torene R, Harbour JW, Forghani I, American journal of medical genetics. Part A 2021 01 185 1 208-212 -
RETINOCYTOMA WITH VITREOUS SEEDING: NEW INSIGHTS FROM ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY AND HIGH-RESOLUTION POSTERIOR SEGMENT ULTRASONOGRAPHY.
Garoon RB, Medina CA, Scelfo C, Harbour JW, Retinal cases & brief reports 2021 Jan 15 1 68-70 -
A novel cardiomyogenic role for Isl1+ neural crest cells in the inflow tract.
Hatzistergos KE, Durante MA, Valasaki K, Wanschel ACBA, Harbour JW, Hare JM, Science advances 2020 Dec 6 49 -
Use of a Modified Plastic Viewing System for Safer General Anesthesia Care in Pediatric Ophthalmic Surgery During the COVID-19 Pandemic.
Ashkenazy N, Orihuela G, Rodriguez LI, Negron CI, Harbour JW, Berrocal AM, Ophthalmic surgery, lasers & imaging retina 2020 11 51 11 651-652 -
Impact of Genetic Ancestry on Prognostic Biomarkers in Uveal Melanoma.
Rodriguez DA, Sanchez MI, Decatur CL, Correa ZM, Martin ER, Harbour JW, Cancers 2020 Oct 12 11 -
Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer.
Carbone M, Harbour JW, Brugarolas J, Bononi A, Pagano I, Dey A, Krausz T, Pass HI, Yang H, Gaudino G, Cancer discovery 2020 08 10 8 1103-1120 -
Bilateral uveitis associated with nivolumab therapy for metastatic non-small cell lung cancer.
Dermarkarian CR, Patel NA, Villegas VM, Harbour JW, American journal of ophthalmology case reports 2020 Jun 18 100691 -
Global Retinoblastoma Presentation and Analysis by National Income Level.
Fabian ID, Abdallah E, Abdullahi SU, Abdulqader RA, Adamou Boubacar S, Ademola-Popoola DS, Adio A, Afshar AR, Aggarwal P, Aghaji AE, Ahmad A, Akib MNR, Al Harby L, Al Ani MH, Alakbarova A, Portabella SA, Al-Badri SAF, Alcasabas APA, Al-Dahmash SA, Alejos A, Alemany-Rubio E, Alfa Bio AI, Alfonso Carreras Y, Al-Haddad C, Al-Hussaini HHY, Ali AM, Alia DB, Al-Jadiry MF, Al-Jumaily U, Alkatan HM, All-Eriksson C, Al-Mafrachi AARM, Almeida AA, Alsawidi KM, Al-Shaheen AASM, Al-Shammary EH, Amiruddin PO, Antonino R, Astbury NJ, Atalay HT, Atchaneeyasakul LO, Atsiaya R, Attaseth T, Aung TH, Ayala S, Baizakova B, Balaguer J, Balayeva R, Balwierz W, Barranco H, Bascaran C, Beck Popovic M, Benavides R, Benmiloud S, Bennani Guebessi N, Berete RC, Berry JL, Bhaduri A, Bhat S, Biddulph SJ, Biewald EM, Bobrova N, Boehme M, Boldt HC, Bonanomi MTBC, Bornfeld N, Bouda GC, Bouguila H, Boumedane A, Brennan RC, Brichard BG, Buaboonnam J, Calderón-Sotelo P, Calle Jara DA, Camuglia JE, Cano MR, Capra M, Cassoux N, Castela G, Castillo L, Català-Mora J, Chantada GL, Chaudhry S, Chaugule SS, Chauhan A, Chawla B, Chernodrinska VS, Chiwanga FS, Chuluunbat T, Cieslik K, Cockcroft RL, Comsa C, Correa ZM, Correa Llano MG, Corson TW, Cowan-Lyn KE, Csóka M, Cui X, Da Gama IV, Dangboon W, Das A, Das S, Davanzo JM, Davidson A, De Potter P, Delgado KQ, Demirci H, Desjardins L, Diaz Coronado RY, Dimaras H, Dodgshun AJ, Donaldson C, Donato Macedo CR, Dragomir MD, Du Y, Du Bruyn M, Edison KS, Eka Sutyawan IW, El Kettani A, Elbahi AM, Elder JE, Elgalaly D, Elhaddad AM, Elhassan MMA, Elzembely MM, Essuman VA, Evina TGA, Fadoo Z, Fandiño AC, Faranoush M, Fasina O, Fernández DDPG, Fernández-Teijeiro A, Foster A, Frenkel S, Fu LD, Fuentes-Alabi SL, Gallie BL, Gandiwa M, Garcia JL, García Aldana D, Gassant PY, Geel JA, Ghassemi F, Girón AV, Gizachew Z, Goenz MA, Gold AS, Goldberg-Lavid M, Gole GA, Gomel N, Gonzalez E, Gonzalez Perez G, González-Rodríguez L, Garcia Pacheco HN, Graells J, Green L, Gregersen PA, Grigorovski NDAK, Guedenon KM, Gunasekera DS, Gündüz AK, Gupta H, Gupta S, Hadjistilianou T, Hamel P, Hamid SA, Hamzah N, Hansen ED, Harbour JW, Hartnett ME, Hasanreisoglu M, Hassan S, Hassan S, Hederova S, Hernandez J, Hernandez LMC, Hessissen L, Hordofa DF, Huang LC, Hubbard GB, Hummlen M, Husakova K, Hussein Al-Janabi AN, Ida R, Ilic VR, Jairaj V, Jeeva I, Jenkinson H, Ji X, Jo DH, Johnson KP, Johnson WJ, Jones MM, Kabesha TBA, Kabore RL, Kaliki S, Kalinaki A, Kantar M, Kao LY, Kardava T, Kebudi R, Kepak T, Keren-Froim N, Khan ZJ, Khaqan HA, Khauv P, Kheir WJ, Khetan V, Khodabande A, Khotenashvili Z, Kim JW, Kim JH, Kiratli H, Kivelä TT, Klett A, Komba Palet JEK, Krivaitiene D, Kruger M, Kulvichit K, Kuntorini MW, Kyara A, Lachmann ES, Lam CPS, Lam GC, Larson SA, Latinovic S, Laurenti KD, Le BHA, Lecuona K, Leverant AA, Li C, Limbu B, Long QB, López JP, Lukamba RM, Lumbroso L, Luna-Fineman S, Lutfi D, Lysytsia L, Magrath GN, Mahajan A, Majeed AR, Maka E, Makan M, Makimbetov EK, Manda C, Martín Begue N, Mason L, Mason JO, Matende IO, Materin M, Mattosinho CCDS, Matua M, Mayet I, Mbumba FB, McKenzie JD, Medina-Sanson A, Mehrvar A, Mengesha AA, Menon V, Mercado GJVD, Mets MB, Midena E, Mishra DKC, Mndeme FG, Mohamedani AA, Mohammad MT, Moll AC, Montero MM, Morales RA, Moreira C, Mruthyunjaya P, Msina MS, Msukwa G, Mudaliar SS, Muma KI, Munier FL, Murgoi G, Murray TG, Musa KO, Mushtaq A, Mustak H, Muyen OM, Naidu G, Nair AG, Naumenko L, Ndoye Roth PA, Nency YM, Neroev V, Ngo H, Nieves RM, Nikitovic M, Nkanga ED, Nkumbe H, Nuruddin M, Nyaywa M, Obono-Obiang G, Oguego NC, Olechowski A, Oliver SCN, Osei-Bonsu P, Ossandon D, Paez-Escamilla MA, Pagarra H, Painter SL, Paintsil V, Paiva L, Pal BP, Palanivelu MS, Papyan R, Parrozzani R, Parulekar M, Pascual Morales CR, Paton KE, Pawinska-Wasikowska K, Pe'er J, Peña A, Peric S, Pham CTM, Philbert R, Plager DA, Pochop P, Polania RA, Polyakov VG, Pompe MT, Pons JJ, Prat D, Prom V, Purwanto I, Qadir AO, Qayyum S, Qian J, Rahman A, Rahman S, Rahmat J, Rajkarnikar P, Ramanjulu R, Ramasubramanian A, Ramirez-Ortiz MA, Raobela L, Rashid R, Reddy MA, Reich E, Renner LA, Reynders D, Ribadu D, Riheia MM, Ritter-Sovinz P, Rojanaporn D, Romero L, Roy SR, Saab RH, Saakyan S, Sabhan AH, Sagoo MS, Said AMA, Saiju R, Salas B, San Román Pacheco S, Sánchez GL, Sayalith P, Scanlan TA, Schefler AC, Schoeman J, Sedaghat A, Seregard S, Seth R, Shah AS, Shakoor SA, Sharma MK, Sherief ST, Shetye NG, Shields CL, Siddiqui SN, Sidi Cheikh S, Silva S, Singh AD, Singh N, Singh U, Singha P, Sitorus RS, Skalet AH, Soebagjo HD, Sorochynska T, Ssali G, Stacey AW, Staffieri SE, Stahl ED, Stathopoulos C, Stirn Kranjc B, Stones DK, Strahlendorf C, Suarez MEC, Sultana S, Sun X, Sundy M, Superstein R, Supriyadi E, Surukrattanaskul S, Suzuki S, Svojgr K, Sylla F, Tamamyan G, Tan D, Tandili A, Tarrillo Leiva FF, Tashvighi M, Tateshi B, Tehuteru ES, Teixeira LF, Teh KH, Theophile T, Toledano H, Trang DL, Traoré F, Trichaiyaporn S, Tuncer S, Tyau-Tyau H, Umar AB, Unal E, Uner OE, Urbak SF, Ushakova TL, Usmanov RH, Valeina S, van Hoefen Wijsard M, Varadisai A, Vasquez L, Vaughan LO, Veleva-Krasteva NV, Verma N, Victor AA, Viksnins M, Villacís Chafla EG, Vishnevskia-Dai V, Vora T, Wachtel AE, Wackernagel W, Waddell K, Wade PD, Wali AH, Wang YZ, Weiss A, Wilson MW, Wime ADC, Wiwatwongwana A, Wiwatwongwana D, Wolley Dod C, Wongwai P, Xiang D, Xiao Y, Yam JC, Yang H, Yanga JM, Yaqub MA, Yarovaya VA, Yarovoy AA, Ye H, Yousef YA, Yuliawati P, Zapata López AM, Zein E, Zhang C, Zhang Y, Zhao J, Zheng X, Zhilyaeva K, Zia N, Ziko OAO, Zondervan M, Bowman R, JAMA oncology 2020 05 6 5 685-695 -
Decitabine limits escape from MEK inhibition in uveal melanoma.
Gonçalves J, Emmons MF, Faião-Flores F, Aplin AE, Harbour JW, Licht JD, Wink MR, Smalley KSM, Pigment cell & melanoma research 2020 05 33 3 507-514 -
Influence of tumor shape and location in eye plaque brachytherapy dosimetry.
Studenski MT, Patel NV, Markoe A, Harbour JW, Samuels SE, Brachytherapy 2020 Mar - Apr 19 2 249-254 -
Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.
Durante MA, Kurtenbach S, Sargi ZB, Harbour JW, Choi R, Kurtenbach S, Goss GM, Matsunami H, Goldstein BJ, Nature neuroscience 2020 03 23 3 323-326 -
Multi-center analysis of intraocular biopsy technique and outcomes for uveal melanoma: Ocular Oncology Study Consortium report 4.
Seider MI, Berry DE, Schefler AC, Materin M, Stinnett S, Mruthyunjaya P, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2020 Feb 258 2 427-435 -
Single-cell analysis reveals new evolutionary complexity in uveal melanoma.
Durante MA, Rodriguez DA, Kurtenbach S, Kuznetsov JN, Sanchez MI, Decatur CL, Snyder H, Feun LG, Livingstone AS, Harbour JW, Nature communications 2020 01 11 1 496 -
Intraocular Metastasis in Unilateral Multifocal Uveal Melanoma Without Melanocytosis or Germline BAP1 Mutations.
Durante MA, Walter SD, Paez-Escamilla M, Tokarev J, Decatur CL, Dubovy SR, Schefler AC, Harbour JW, JAMA ophthalmology 2019 12 137 12 1434-1439 -
HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma.
Faião-Flores F, Emmons MF, Durante MA, Kinose F, Saha B, Fang B, Koomen JM, Chellappan SP, Maria-Engler SS, Rix U, Licht JD, Harbour JW, Smalley KSM, Clinical cancer research : an official journal of the American Association for Cancer Research 2019 09 25 18 5686-5701 -
BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas.
Field MG, Kuznetsov JN, Bussies PL, Cai LZ, Alawa KA, Decatur CL, Kurtenbach S, Harbour JW, Clinical cancer research : an official journal of the American Association for Cancer Research 2019 09 25 18 5663-5673 -
Intraocular Dissemination of Uveal Melanoma Cells Following Radiotherapy: Evolving Management Over the Past Decade.
Paez-Escamilla M, Walter SD, Mohsenin A, Decatur CL, Harocopos GJ, Dubovy S, Harbour JW, Ophthalmic surgery, lasers & imaging retina 2019 09 50 9 573-579 -
BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers.
Kuznetsov JN, Aguero TH, Owens DA, Kurtenbach S, Field MG, Durante MA, Rodriguez DA, King ML, Harbour JW, Science advances 2019 09 5 9 eaax1738 -
Integrative Copy Number Analysis of Uveal Melanoma Reveals Novel Candidate Genes Involved in Tumorigenesis Including a Tumor Suppressor Role for PHF10/BAF45a.
Anbunathan H, Verstraten R, Singh AD, Harbour JW, Bowcock AM, Clinical cancer research : an official journal of the American Association for Cancer Research 2019 08 25 16 5156-5166 -
Genomic evolution of uveal melanoma arising in ocular melanocytosis.
Durante MA, Field MG, Sanchez MI, Covington KR, Decatur CL, Dubovy SR, Harbour JW, Cold Spring Harbor molecular case studies 2019 08 5 4 -
Vitreoretinal lymphoma followed by systemic diffuse large B cell lymphoma.
Fan KC, Tran KD, Harbour JW, Dubovy SA, Patel NA, Albini TA, Journal of ophthalmic inflammation and infection 2019 Jun 9 1 11 -
CD4+/CD8+ immunophenotype switching as a marker for intraocular and CNS involvement in mycosis fungoides.
Husnain M, Mackrides N, Vega F, Paez-Escamilla M, Markoe AM, Harbour JW, Lossos IS, Leukemia & lymphoma 2019 05 60 5 1308-1311 -
Dosimetric comparison of circular Eye Physics and Collaborative Ocular Melanoma Study plaques to treat uveal melanoma.
Dean MK, Studenski MT, Paez-Escamilla MA, Walter SD, Kwon D, Markoe AM, Harbour JW, Samuels SE, Brachytherapy 2019 May - Jun 18 3 404-410 -
An Eight-Year-Old Girl Presents With Two Weeks of Vision Loss and Nightly Headaches.
Scott NL, Tran KD, Cernichiaro-Espinosa LA, Russell JF, Hinkle JW, Harbour JW, Dubovy SR, Berrocal AM, Ophthalmic surgery, lasers & imaging retina 2019 05 50 5 314-317 -
Bilateral radiation therapy followed by methotrexate-based chemotherapy for primary vitreoretinal lymphoma.
de la Fuente MI, Alderuccio JP, Reis IM, Omuro A, Markoe A, Echegaray JJ, Davis JL, Harbour JW, Lossos IS, American journal of hematology 2019 04 94 4 455-460 -
Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study.
Jeng-Miller KW, Soomro T, Scott NL, Rao P, Marlow E, Chang EY, Ells A, Chau F, Nudleman E, Calvo CM, Patel N, Schwartz R, Cernichiaro-Espinosa LA, Montoya AG, Goldstein J, Harper CA, Baumal CR, Hartnett ME, Harbour JW, Besirli CG, Gupta MP, Chan RVP, Drenser KA, Capone A, Murray TG, Mukai S, Trese MT, Berrocal AM, Wong SC, Yonekawa Y, Ophthalmic surgery, lasers & imaging retina 2019 04 50 4 221-227 -
Persistent fetal vasculature presenting with axial elongation and platyphakia.
Lin J, Paez-Escamilla M, Teira LE, Fallas B, Harbour JW, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 2019 02 23 1 51-53 -
Are Risk Factors for Growth of Choroidal Nevi Associated With Malignant Transformation? Assessment With a Validated Genomic Biomarker.
Harbour JW, Paez-Escamilla M, Cai L, Walter SD, Augsburger JJ, Correa ZM, American journal of ophthalmology 2019 01 197 168-179 -
ChIPprimersDB: a public repository of verified qPCR primers for chromatin immunoprecipitation (ChIP).
Kurtenbach S, Reddy R, Harbour JW, Nucleic acids research 2019 01 47 D1 D46-D49 -
Follow the nevus: the cost-utility of monitoring for growth of choroidal nevi.
Barsam AS, Gibbons A, McClellan AJ, Harbour JW, Smiddy WE, International journal of ophthalmology 2019 12 9 1456-1464 -
Drug and disease signature integration identifies synergistic combinations in glioblastoma.
Stathias V, Jermakowicz AM, Maloof ME, Forlin M, Walters W, Suter RK, Durante MA, Williams SL, Harbour JW, Volmar CH, Lyons NJ, Wahlestedt C, Graham RM, Ivan ME, Komotar RJ, Sarkaria JN, Subramanian A, Golub TR, Schürer SC, Ayad NG, Nature communications 2018 12 9 1 5315 -
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Walpole S, Pritchard AL, Cebulla CM, Pilarski R, Stautberg M, Davidorf FH, de la Fouchardière A, Cabaret O, Golmard L, Stoppa-Lyonnet D, Garfield E, Njauw CN, Cheung M, Turunen JA, Repo P, Järvinen RS, van Doorn R, Jager MJ, Luyten GPM, Marinkovic M, Chau C, Potrony M, Höiom V, Helgadottir H, Pastorino L, Bruno W, Andreotti V, Dalmasso B, Ciccarese G, Queirolo P, Mastracci L, Wadt K, Kiilgaard JF, Speicher MR, van Poppelen N, Kilic E, Al-Jamal RT, Dianzani I, Betti M, Bergmann C, Santagata S, Dahiya S, Taibjee S, Burke J, Poplawski N, O'Shea SJ, Newton-Bishop J, Adlard J, Adams DJ, Lane AM, Kim I, Klebe S, Racher H, Harbour JW, Nickerson ML, Murali R, Palmer JM, Howlie M, Symmons J, Hamilton H, Warrier S, Glasson W, Johansson P, Robles-Espinoza CD, Ossio R, de Klein A, Puig S, Ghiorzo P, Nielsen M, Kivelä TT, Tsao H, Testa JR, Gerami P, Stern MH, Paillerets BB, Abdel-Rahman MH, Hayward NK, Journal of the National Cancer Institute 2018 12 110 12 1328-1341 -
Gene Expression Profiling and PRAME Status Versus Tumor-Node-Metastasis Staging for Prognostication in Uveal Melanoma.
Cai L, Paez-Escamilla M, Walter SD, Tarlan B, Decatur CL, Perez BM, Harbour JW, American journal of ophthalmology 2018 11 195 154-160 -
Diagnosis of Bilateral Retinocytoma in an Adolescent Patient Using Multimodal Imaging and Genetic Testing.
Paez-Escamilla M, Walter SD, Ramaiya KJ, Harbour JW, Ophthalmic surgery, lasers & imaging retina 2018 10 49 10 812-814 -
Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo.
Guo Y, Yang H, Chen S, Zhang P, Li R, Nimer SD, Harbour JW, Xu M, Yang FC, Leukemia 2018 08 32 8 1834-1837 -
Anterior Chamber Chemotherapy in Retinoblastoma-Necessary But Not Sufficient for Aqueous Seeding Control-Reply.
Harbour JW, Paez-Escamilla M, JAMA ophthalmology 2018 05 136 5 597 -
Congenital Hypertrophy of the Retinal Pigment Epithelium Presenting With Secondary Choroidal Neovascularization.
Garoon RB, Harbour JW, Ophthalmic surgery, lasers & imaging retina 2018 04 49 4 276-277 -
Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains.
Peng H, Prokop J, Karar J, Park K, Cao L, Harbour JW, Bowcock AM, Malkowicz SB, Cheung M, Testa JR, Rauscher FJ, Cancer research 2018 03 78 5 1200-1213 -
Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.
Yang H, Kurtenbach S, Guo Y, Lohse I, Durante MA, Li J, Li Z, Al-Ali H, Li L, Chen Z, Field MG, Zhang P, Chen S, Yamamoto S, Li Z, Zhou Y, Nimer SD, Harbour JW, Wahlestedt C, Xu M, Yang FC, Blood 2018 01 131 3 328-341 -
Punctuated evolution of canonical genomic aberrations in uveal melanoma.
Field MG, Durante MA, Anbunathan H, Cai LZ, Decatur CL, Bowcock AM, Kurtenbach S, Harbour JW, Nature communications 2018 01 9 1 116 -
Retinoblastoma With Endophytic and Exophytic Features.
Paez-Escamilla M, Bagheri N, Harbour JW, JAMA ophthalmology 2018 Jan 136 1 e175064 -
Intracameral Topotecan Hydrochloride for Anterior Chamber Seeding of Retinoblastoma.
Paez-Escamilla M, Bagheri N, Teira LE, Corrales-Medina FF, Harbour W, JAMA ophthalmology 2017 Dec 135 12 1453-1454 -
Molecular Characteristics of Conjunctival Melanoma Using Whole-Exome Sequencing.
Swaminathan SS, Field MG, Sant D, Wang G, Galor A, Dubovy SR, Harbour JW, Karp CL, JAMA ophthalmology 2017 12 135 12 1434-1437 -
Liquid Biopsy in Retinoblastoma.
Harbour JW, JAMA ophthalmology 2017 11 135 11 1231 -
Letter to the Editor: Comparison of Alternative Tumor Size Classifications for Posterior Uveal Melanomas.
Harbour JW, Paez-Escamilla M, Investigative ophthalmology & visual science 2017 10 58 12 5444 -
Multimodal Imaging of Astrocytic Hamartomas Associated With Tuberous Sclerosis.
Schwartz SG, Harbour JW, Ophthalmic surgery, lasers & imaging retina 2017 09 48 9 756-758 -
Fluorescein angiography findings in diffuse retinoblastoma: two case reports with clinicopathologic correlation.
Fernandez MP, Al-Holou SN, Fischer O, Murray T, Harbour JW, Dubovy SR, Berrocal AM, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 2017 Aug 21 4 337-339.e2 -
Incorporating Clinical, Histological, and Genetic Parameters for Choroidal Melanoma Prognostication-Reply.
Harbour JW, JAMA ophthalmology 2017 07 135 7 819-820 -
PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma.
Gezgin G, Luk SJ, Cao J, Dogrusöz M, van der Steen DM, Hagedoorn RS, Krijgsman D, van der Velden PA, Field MG, Luyten GPM, Szuhai K, Harbour JW, Jordanova ES, Heemskerk MHM, Jager MJ, JAMA ophthalmology 2017 06 135 6 541-549 -
Association between Tumor Regression Rate and Gene Expression Profile after Iodine 125 Plaque Radiotherapy for Uveal Melanoma.
Mruthyunjaya P, Seider MI, Stinnett S, Schefler A Ophthalmology 2017 May -
Prognostic Implications of the Largest Basal Tumor Diameter vs the TNM Staging System in Association With the Gene Expression Profile for Uveal Melanoma-Reply.
Harbour JW, JAMA ophthalmology 2017 Feb 135 2 175-176 -
Preclinical Acute Ocular Safety Study of Combined Intravitreal Carboplatin and Etoposide Phosphate for Retinoblastoma.
Mohney BG, Elner VM, Smith AB, Harbour JW, Smith BD, Musch DC, Smith SJ, Ophthalmic surgery, lasers & imaging retina 2017 02 48 2 151-159 -
An international survey of classification and treatment choices for group D retinoblastoma.
Scelfo C, Francis JH, Khetan V, Jenkins T, Marr B, Abramson DH, Shields CL, Pe'er J, Munier F, Berry J, Harbour JW, Yarovoy A, Lucena E, Murray TG, Bhagia P, Paysse E, Tuncer S, Chantada GL, Moll AC, Ushakova T, Plager DA, Ziyovuddin I, Leal CA, Materin MA, Ji XD, Cursino JW, Polania R, Kiratli H, All-Ericsson C, Kebudi R, Honavar SG, Vishnevskia-Dai V, Epelman S, Daniels AB, Ling JD, Traore F, Ramirez-Ortiz MA, International journal of ophthalmology 2017 10 6 961-967 -
ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis.
Li Z, Zhang P, Yan A, Guo Z, Ban Y, Li J, Chen S, Yang H, He Y, Li J, Guo Y, Zhang W, Hajiramezanali E, An H, Fajardo D, Harbour JW, Ruan Y, Nimer SD, Yu P, Chen X, Xu M, Yang FC, Science advances 2017 Jan 3 1 e1601602 -
A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature.
Fedorenko IV, Evernden B, Kenchappa RS, Sahebjam S, Ryzhova E, Puskas J, McIntosh L, Caceres G, Magliocco A, Etame A, Harbour JW, Smalley KS, Forsyth PA, Melanoma research 2016 10 26 5 481-6 -
An Iris Tumor.
Rao RC, Harbour JW, JAMA ophthalmology 2016 09 134 9 1063-4 -
Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in Class 1 and Class 2 uveal melanomas.
Field MG, Durante MA, Decatur CL, Tarlan B, Oelschlager KM, Stone JF, Kuznetsov J, Bowcock AM, Kurtenbach S, Harbour JW, Oncotarget 2016 Sep 7 37 59209-59219 -
The state of melanoma: challenges and opportunities.
Merlino G, Herlyn M, Fisher DE, Bastian BC, Flaherty KT, Davies MA, Wargo JA, Curiel-Lewandrowski C, Weber MJ, Leachman SA, Soengas MS, McMahon M, Harbour JW, Swetter SM, Aplin AE, Atkins MB, Bosenberg MW, Dummer R, Gershenwald JE, Halpern AC, Herlyn D, Karakousis GC, Kirkwood JM, Krauthammer M, Lo RS, Long GV, McArthur G, Ribas A, Schuchter L, Sosman JA, Smalley KS, Steeg P, Thomas NE, Tsao H, Tueting T, Weeraratna A, Xu G, Lomax R, Martin A, Silverstein S, Turnham T, Ronai ZA, Pigment cell & melanoma research 2016 07 29 4 404-16 -
Prognostic Implications of Tumor Diameter in Association With Gene Expression Profile for Uveal Melanoma.
Walter SD, Chao DL, Feuer W, Schiffman J, Char DH, Harbour JW, JAMA ophthalmology 2016 Jul 134 7 734-40 -
Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes.
Decatur CL, Ong E, Garg N, Anbunathan H, Bowcock AM, Field MG, Harbour JW, JAMA ophthalmology 2016 07 134 7 728-33 -
ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma.
Yoo JH, Shi DS, Grossmann AH, Sorensen LK, Tong Z, Mleynek TM, Rogers A, Zhu W, Richards JR, Winter JM, Zhu J, Dunn C, Bajji A, Shenderovich M, Mueller AL, Woodman SE, Harbour JW, Thomas KR, Odelberg SJ, Ostanin K, Li DY, Cancer cell 2016 06 29 6 889-904 -
PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma.
Field MG, Decatur CL, Kurtenbach S, Gezgin G, van der Velden PA, Jager MJ, Kozak KN, Harbour JW, Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Mar 22 5 1234-42 -
Uveal and Conjunctival Melanoma: Close Together-but Only Distantly Related.
Harbour JW, Oncology (Williston Park, N.Y.) 2016 Jan 30 1 44, 48 -
Spectral-Domain Optical Coherence Tomography of Presumed Solitary Circumscribed Retinal Astrocytic Proliferation Versus Astrocytic Hamartoma.
Schwartz SG, Harbour JW, Ophthalmic surgery, lasers & imaging retina 2015 May 46 5 586-8 -
Serous macular detachment following a systemic corticosteroid injection.
Weng CY, Harbour JW, JAMA ophthalmology 2015 Apr 133 4 473-4 -
Hydroxyapatite versus polyethylene orbital implants for patients undergoing enucleation for uveal melanoma.
Chao DL, Harbour JW, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 2015 Apr 50 2 151-4 -
Gene expression profiling and regression rate of irradiated uveal melanomas.
Rao RC, Khan M, Badiyan SN, Harbour JW, Ophthalmic surgery, lasers & imaging retina 2015 Mar 46 3 333-7 -
Epigenetic reprogramming of melanoma cells by vitamin C treatment.
Gustafson CB, Yang C, Dickson KM, Shao H, Van Booven D, Harbour JW, Liu ZJ, Wang G, Clinical epigenetics 2015 7 51 -
EMT-associated factors promote invasive properties of uveal melanoma cells.
Asnaghi L, Gezgin G, Tripathy A, Handa JT, Merbs SL, van der Velden PA, Jager MJ, Harbour JW, Eberhart CG, Molecular vision 2015 21 919-29 -
Skewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma.
Herlihy N, Dogrusöz M, van Essen TH, Harbour JW, van der Velden PA, van Eggermond MC, Haasnoot GW, van den Elsen PJ, Jager MJ, Investigative ophthalmology & visual science 2015 Jan 56 3 1447-58 -
Prognostic parameters in uveal melanoma and their association with BAP1 expression.
van Essen TH, van Pelt SI, Versluis M, Bronkhorst IH, van Duinen SG, Marinkovic M, Kroes WG, Ruivenkamp CA, Shukla S, de Klein A, Kiliç E, Harbour JW, Luyten GP, van der Velden PA, Verdijk RM, Jager MJ, The British journal of ophthalmology 2014 Dec 98 12 1738-43 -
Rapid regression of a subset of class 1 uveal melanomas after Iodine-125 plaque radiotherapy suggests an inflammatory mechanism.
Chen RW, Harbour JW, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2014 Dec 252 12 2021-2 -
Combined PKC and MEK inhibition for treating metastatic uveal melanoma.
Sagoo MS, Harbour JW, Stebbing J, Bowcock AM, Oncogene 2014 Sep 33 39 4722-3 -
A molecular revolution in uveal melanoma: implications for patient care and targeted therapy.
Harbour JW, Chao DL, Ophthalmology 2014 Jun 121 6 1281-8 -
GNAQ/11 mutations in uveal melanoma: is YAP the key to targeted therapy?
Field MG, Harbour JW, Cancer cell 2014 Jun 25 6 714-5 -
Recent developments in prognostic and predictive testing in uveal melanoma.
Field MG, Harbour JW, Current opinion in ophthalmology 2014 May 25 3 234-9 -
Distinguishing torpedo maculopathy from similar lesions of the posterior segment.
Villegas VM, Schwartz SG, Flynn HW, Capó H, Berrocal AM, Murray TG, Harbour JW, Ophthalmic surgery, lasers & imaging retina 2014 May-Jun 45 3 222-6 -
Outcomes of iodine-125 plaque brachytherapy for uveal melanoma with intraoperative ultrasonography and supplemental transpupillary thermotherapy.
Badiyan SN, Rao RC, Apicelli AJ, Acharya S, Verma V, Garsa AA, DeWees T, Speirs CK, Garcia-Ramirez J, Esthappan J, Grigsby PW, Harbour JW, International journal of radiation oncology, biology, physics 2014 Mar 88 4 801-5 -
A prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile.
Harbour JW, Methods in molecular biology (Clifton, N.J.) 2014 1102 427-40 -
Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction.
Fu M, Landreville S, Agapova OA, Wiley LA, Shoykhet M, Harbour JW, Heuckeroth RO, The Journal of clinical investigation 2013 Dec 123 12 5152-64 -
Multimodal imaging of sarcoid choroidal granulomas.
Modi YS, Epstein A, Bhaleeya S, Harbour JW, Albini T, Journal of ophthalmic inflammation and infection 2013 Aug 3 1 58 -
BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma.
Matatall KA, Agapova OA, Onken MD, Worley LA, Bowcock AM, Harbour JW, BMC cancer 2013 Aug 13 371 -
Gene expression profiling versus TNM classification.
Harbour JW, Augsburger JJ, Char DH, Ophthalmology 2013 Jul 120 7 e52-3 -
Author reply: To PMID 22521086.
Harbour JW, Augsburger JJ, Char DH, Ophthalmology 2013 Jul 120 7 e51 -
Patient-derived xenografts recapitulate molecular features of human uveal melanomas.
Laurent C, Gentien D, Piperno-Neumann S, Némati F, Nicolas A, Tesson B, Desjardins L, Mariani P, Rapinat A, Sastre-Garau X, Couturier J, Hupé P, de Koning L, Dubois T, Roman-Roman S, Stern MH, Barillot E, Harbour JW, Saule S, Decaudin D, Molecular oncology 2013 Jun 7 3 625-36 -
The DecisionDx-UM Gene Expression Profile Test Provides Risk Stratification and Individualized Patient Care in Uveal Melanoma.
Harbour JW, Chen R, PLoS currents 2013 Apr 5 -
Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.
Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, Apte RS, Cell metabolism 2013 Apr 17 4 549-61 -
Molecular testing prognostic of low risk in epithelioid uveal melanoma in a child.
Dimaras H, Parulekar MV, Kwok G, Simpson ER, Ali A, Halliday W, Shago M, Harbour JW, Héon E, Gallie BL, Chan HS, The British journal of ophthalmology 2013 Mar 97 3 323-6 -
Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma.
Harbour JW, Roberson ED, Anbunathan H, Onken MD, Worley LA, Bowcock AM, Nature genetics 2013 Feb 45 2 133-5 -
Gene expressing profiling of iris melanomas.
Harbour JW, Wilson D, Finger PT, Worley LA, Onken MD, Ophthalmology 2013 Jan 120 1 213, 213.e1-3 -
Genomic, prognostic, and cell-signaling advances in uveal melanoma.
Harbour JW, American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting 2013 388-91 -
A role for Jag2 in promoting uveal melanoma dissemination and growth.
Asnaghi L, Handa JT, Merbs SL, Harbour JW, Eberhart CG, Investigative ophthalmology & visual science 2013 Jan 54 1 295-306 -
High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.
Daniels AB, Lee JE, MacConaill LE, Palescandolo E, Van Hummelen P, Adams SM, DeAngelis MM, Hahn WC, Gragoudas ES, Harbour JW, Garraway LA, Kim IK, Investigative ophthalmology & visual science 2012 Oct 53 11 6991-6 -
Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma.
Onken MD, Worley LA, Char DH, Augsburger JJ, Correa ZM, Nudleman E, Aaberg TM, Altaweel MM, Bardenstein DS, Finger PT, Gallie BL, Harocopos GJ, Hovland PG, McGowan HD, Milman T, Mruthyunjaya P, Simpson ER, Smith ME, Wilson DJ, Wirostko WJ, Harbour JW, Ophthalmology 2012 Aug 119 8 1596-603 -
Uveal melanoma: molecular pattern, clinical features, and radiation response.
Chappell MC, Char DH, Cole TB, Harbour JW, Mishra K, Weinberg VK, Phillips TL, American journal of ophthalmology 2012 Aug 154 2 227-232.e2 -
Update in uveal melanoma.
Harbour JW, Clinical advances in hematology & oncology : H&O 2012 Jul 10 7 459-61 -
The genetics of uveal melanoma: an emerging framework for targeted therapy.
Harbour JW, Pigment cell & melanoma research 2012 Mar 25 2 171-81 -
Notch signaling promotes growth and invasion in uveal melanoma.
Asnaghi L, Ebrahimi KB, Schreck KC, Bar EE, Coonfield ML, Bell WR, Handa J, Merbs SL, Harbour JW, Eberhart CG, Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Feb 18 3 654-65 -
Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.
Landreville S, Agapova OA, Matatall KA, Kneass ZT, Onken MD, Lee RS, Bowcock AM, Harbour JW, Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Jan 18 2 408-16 -
A new mutation with staggering effects.
Harbour JW, Pigment cell & melanoma research 2011 Dec 24 6 1081-2 -
ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity.
Landreville S, Agapova OA, Kneass ZT, Salesse C, Harbour JW, Pigment cell & melanoma research 2011 Jun 24 3 430-7 -
Diagnostic testing and treatment choices in primary vitreoretinal lymphoma.
Rajagopal R, Harbour JW, Retina (Philadelphia, Pa.) 2011 Mar 31 3 435-40 -
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.
Delston RB, Matatall KA, Sun Y, Onken MD, Harbour JW, Oncogene 2011 Feb 30 5 588-99 -
Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium.
Chan CC, Rubenstein JL, Coupland SE, Davis JL, Harbour JW, Johnston PB, Cassoux N, Touitou V, Smith JR, Batchelor TT, Pulido JS, The oncologist 2011 16 11 1589-99 -
Frequent mutation of BAP1 in metastasizing uveal melanomas.
Harbour JW, Onken MD, Roberson ED, Duan S, Cao L, Worley LA, Council ML, Matatall KA, Helms C, Bowcock AM, Science (New York, N.Y.) 2010 Dec 330 6009 1410-3 -
Association between gene expression profile, proliferation and metastasis in uveal melanoma.
Onken MD, Worley LA, Harbour JW, Current eye research 2010 Sep 35 9 857-63 -
Review of 676 second primary tumors in patients with retinoblastoma: association between age at onset and tumor type.
Woo KI, Harbour JW, Archives of ophthalmology (Chicago, Ill. : 1960) 2010 Jul 128 7 865-70 -
An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma.
Onken MD, Worley LA, Tuscan MD, Harbour JW, The Journal of molecular diagnostics : JMD 2010 Jul 12 4 461-8 -
Loss of Id2 potentiates the tumorigenic effect of Rb inactivation in a mouse model of retinoblastoma.
Landreville S, Ma D, Wu J, Harbour JW, Current eye research 2010 May 35 5 435-9 -
A transformation in ocular oncology: from megacenter to multicenter.
Harbour JW, Archives of ophthalmology (Chicago, Ill. : 1960) 2010 Mar 128 3 367-8 -
Id2 deficiency promotes metastasis in a mouse model of ocular cancer.
Agapova OA, Person E, Harbour JW, Clinical & experimental metastasis 2010 Feb 27 2 91-6 -
Molecular prognostic testing and individualized patient care in uveal melanoma.
Harbour JW, American journal of ophthalmology 2009 Dec 148 6 823-9.e1 -
The 7th edition AJCC staging system for eye cancer: an international language for ophthalmic oncology.
Finger PT, Archives of pathology & laboratory medicine 2009 Aug 133 8 1197-8 -
Hepatic metastasis from uveal melanoma: angiographic pattern predictive of survival after hepatic arterial chemoembolization.
Dayani PN, Gould JE, Brown DB, Sharma KV, Linette GP, Harbour JW, Archives of ophthalmology (Chicago, Ill. : 1960) 2009 May 127 5 628-32 -
Oncogenic mutations in GNAQ occur early in uveal melanoma.
Onken MD, Worley LA, Long MD, Duan S, Council ML, Bowcock AM, Harbour JW, Investigative ophthalmology & visual science 2008 Dec 49 12 5230-4 -
Emerging insights into the molecular pathogenesis of uveal melanoma.
Landreville S, Agapova OA, Harbour JW, Future oncology (London, England) 2008 Oct 4 5 629-36 -
Comment on "Lowpenetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras" by Park et al.
Harbour JW, Cell cycle (Georgetown, Tex.) 2008 Aug 7 15 2276-7 -
Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling.
Worley LA, Long MD, Onken MD, Harbour JW, Melanoma research 2008 Jun 18 3 184-90 -
A metastasis modifier locus on human chromosome 8p in uveal melanoma identified by integrative genomic analysis.
Onken MD, Worley LA, Harbour JW, Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Jun 14 12 3737-45 -
Prognostic biomarkers in uveal melanoma: evidence for a stem cell-like phenotype associated with metastasis.
Chang SH, Worley LA, Onken MD, Harbour JW, Melanoma research 2008 Jun 18 3 191-200 -
Correlation study of benign cytomorphology and final clinical diagnosis.
Zhai J, Harbour JW, Smith ME, Dávila RM, Acta cytologica 2008 Mar-Apr 52 2 196-200 -
Integrative genomic analysis of aneuploidy in uveal melanoma.
Ehlers JP, Worley L, Onken MD, Harbour JW, Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Jan 14 1 115-22 -
Tilting of radioactive plaques after initial accurate placement for treatment of uveal melanoma.
Almony A, Breit S, Zhao H, Garcia-Ramirez J, Mansur DB, Harbour JW, Archives of ophthalmology (Chicago, Ill. : 1960) 2008 Jan 126 1 65-70 -
Hepatic arterial chemoembolization for management of metastatic melanoma.
Sharma KV, Gould JE, Harbour JW, Linette GP, Pilgram TK, Dayani PN, Brown DB, AJR. American journal of roentgenology 2008 Jan 190 1 99-104 -
Treatment outcomes for primary intraocular lymphoma: implications for external beam radiotherapy.
Berenbom A, Davila RM, Lin HS, Harbour JW, Eye (London, England) 2007 Sep 21 9 1198-201 -
Molecular prognostic testing in uveal melanoma: has it finally come of age?
Harbour JW, Archives of ophthalmology (Chicago, Ill. : 1960) 2007 Aug 125 8 1122-3 -
Loss of heterozygosity of chromosome 3 detected with single nucleotide polymorphisms is superior to monosomy 3 for predicting metastasis in uveal melanoma.
Onken MD, Worley LA, Person E, Char DH, Bowcock AM, Harbour JW, Clinical cancer research : an official journal of the American Association for Cancer Research 2007 May 13 10 2923-7 -
Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma.
Worley LA, Onken MD, Person E, Robirds D, Branson J, Char DH, Perry A, Harbour JW, Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Mar 13 5 1466-71 -
Inhibiting angiogenesis in retinoblastoma.
Apte RS, Harbour JW, Ophthalmic research 2007 39 4 188-90 -
Rb at the interface between cell cycle and apoptotic decisions.
Delston RB, Harbour JW, Current molecular medicine 2006 Nov 6 7 713-8 -
Prognostic testing in uveal melanoma by transcriptomic profiling of fine needle biopsy specimens.
Onken MD, Worley LA, Dávila RM, Char DH, Harbour JW, The Journal of molecular diagnostics : JMD 2006 Nov 8 5 567-73 -
Eye cancer: unique insights into oncogenesis: the Cogan Lecture.
Harbour JW, Investigative ophthalmology & visual science 2006 May 47 5 1736-45 -
Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas.
Onken MD, Ehlers JP, Worley LA, Makita J, Yokota Y, Harbour JW, Cancer research 2006 May 66 9 4602-9 -
Lipid exudation following plaque radiotherapy for posterior uveal melanoma.
Mills MD, Harbour JW, American journal of ophthalmology 2006 Mar 141 3 594-595 -
Molecular pathobiology of uveal melanoma.
Ehlers JP, Harbour JW, International ophthalmology clinics 2006 46 1 167-80 -
Association between microarray gene expression signature and extravascular matrix patterns in primary uveal melanomas.
Onken MD, Lin AY, Worley LA, Folberg R, Harbour JW, American journal of ophthalmology 2005 Oct 140 4 748-9 -
Functional analysis of the p53 pathway in response to ionizing radiation in uveal melanoma.
Sun Y, Tran BN, Worley LA, Delston RB, Harbour JW, Investigative ophthalmology & visual science 2005 May 46 5 1561-4 -
DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma.
Ehlers JP, Worley L, Onken MD, Harbour JW, Clinical cancer research : an official journal of the American Association for Cancer Research 2005 May 11 10 3609-13 -
Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management.
Faulkner-Jones BE, Foster WJ, Harbour JW, Smith ME, Dávila RM, Acta cytologica 2005 May-Jun 49 3 297-308 -
NBS1 expression as a prognostic marker in uveal melanoma.
Ehlers JP, Harbour JW, Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Mar 11 5 1849-53 -
Uveal melanoma: genetic aspects.
Singh AD, Damato B, Howard P, Harbour JW, Ophthalmology clinics of North America 2005 Mar 18 1 85-97, viii -
Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase.
Lieman JH, Worley LA, Harbour JW, The Journal of biological chemistry 2005 Mar 280 11 10484-90 -
MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A.
Loercher AE, Tank EM, Delston RB, Harbour JW, The Journal of cell biology 2005 Jan 168 1 35-40 -
Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death.
Onken MD, Worley LA, Ehlers JP, Harbour JW, Cancer research 2004 Oct 64 20 7205-9 -
What is the best treatment for retinoblastoma?
Harbour JW, American journal of ophthalmology 2004 Sep 138 3 471-3 -
Cytologic diagnosis of intraocular lymphoma in vitreous aspirates.
Farkas T, Harbour JW, Dávila RM, Acta cytologica 2004 Jul-Aug 48 4 487-91 -
Photodynamic therapy for choroidal metastasis from carcinoid tumor.
Harbour JW, American journal of ophthalmology 2004 Jun 137 6 1143-5 -
For whom the bell tolls: susceptibility to common adult cancers in retinoblastoma survivors.
Kaye FJ, Harbour JW, Journal of the National Cancer Institute 2004 Mar 96 5 342-3 -
Optical coherence tomography in the evaluation of retinal changes associated with suspicious choroidal melanocytic tumors.
Espinoza G, Rosenblatt B, Harbour JW, American journal of ophthalmology 2004 Jan 137 1 90-5 -
Association between choroidal pigmentation and posterior uveal melanoma in a white population.
Harbour JW, Brantley MA, Hollingsworth H, Gordon M, The British journal of ophthalmology 2004 Jan 88 1 39-43 -
Association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi.
Harbour JW, Brantley MA, Hollingsworth H, Gordon M, The British journal of ophthalmology 2004 Jan 88 1 36-8 -
Transpupillary thermotherapy versus plaque radiotherapy for suspected choroidal melanomas.
Harbour JW, Meredith TA, Thompson PA, Gordon ME, Ophthalmology 2003 Nov 110 11 2207-14; discussion 2215 -
Status of the NF1 tumor suppressor locus in uveal melanoma.
Foster WJ, Fuller CE, Perry A, Harbour JW, Archives of ophthalmology (Chicago, Ill. : 1960) 2003 Sep 121 9 1311-5 -
Pars plana vitrectomy in eyes containing a treated posterior uveal melanoma.
Foster WJ, Harbour JW, Holekamp NM, Shah GK, Thomas MA, American journal of ophthalmology 2003 Sep 136 3 471-6 -
Ocular melanoma: a review and the relationship to cutaneous melanoma.
Hurst EA, Harbour JW, Cornelius LA, Archives of dermatology 2003 Aug 139 8 1067-73 -
Molecular genetics of uveal melanoma.
Loercher AE, Harbour JW, Current eye research 2003 Aug 27 2 69-74 -
Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb.
Ma D, Zhou P, Harbour JW, The Journal of biological chemistry 2003 May 278 21 19358-66 -
Rate of resolution of exudative retinal detachment after plaque radiotherapy for uveal melanoma.
Harbour JW, Ahmad S, El-Bash M, Archives of ophthalmology (Chicago, Ill. : 1960) 2002 Nov 120 11 1463-9 -
Transducible peptide therapy for uveal melanoma and retinoblastoma.
Harbour JW, Worley L, Ma D, Cohen M, Archives of ophthalmology (Chicago, Ill. : 1960) 2002 Oct 120 10 1341-6 -
Photodynamic therapy for circumscribed choroidal hemangioma.
Sheidow TG, Harbour JW, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 2002 Aug 37 5 314-7 -
Altered expression of Rb and p53 in uveal melanomas following plaque radiotherapy.
Brantley MA, Worley L, Harbour JW, American journal of ophthalmology 2002 Feb 133 2 242-8 -
Risk factors for metastasis in retinoblastoma.
Finger PT, Harbour JW, Karcioglu ZA, Survey of ophthalmology 2002 Jan-Feb 47 1 1-16 -
Molecular basis of low-penetrance retinoblastoma.
Harbour JW, Archives of ophthalmology (Chicago, Ill. : 1960) 2001 Nov 119 11 1699-704 -
The molecular biology of retinoblastoma.
Brantley MA, Harbour JW, Ocular immunology and inflammation 2001 Mar 9 1 1-8 -
Corepressors and retinoblastoma protein function.
Harbour JW, Dean DC, Current topics in microbiology and immunology 2001 254 137-44 -
Chromatin remodeling and Rb activity.
Harbour JW, Dean DC, Current opinion in cell biology 2000 Dec 12 6 685-9 -
Deregulation of the Rb and p53 pathways in uveal melanoma.
Brantley MA, Harbour JW, The American journal of pathology 2000 Dec 157 6 1795-801 -
The Rb/E2F pathway: expanding roles and emerging paradigms.
Harbour JW, Dean DC, Genes & development 2000 Oct 14 19 2393-409 -
Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region.
Brantley MA, Harbour JW, Cancer research 2000 Aug 60 16 4320-3 -
Rb function in cell-cycle regulation and apoptosis.
Harbour JW, Dean DC, Nature cell biology 2000 Apr 2 4 E65-7 -
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.
Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX, Harbour JW, Dean DC, Cell 2000 Mar 101 1 79-89 -
Tumor suppressor genes in ophthalmology.
Harbour JW, Survey of ophthalmology 1999 Nov-Dec 44 3 235-46 -
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.
Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC, Cell 1999 Sep 98 6 859-69 -
Overview of RB gene mutations in patients with retinoblastoma. Implications for clinical genetic screening.
Harbour JW, Ophthalmology 1998 Aug 105 8 1442-7 -
Metastatic risk for distinct patterns of postirradiation local recurrence of posterior uveal melanoma.
Harbour JW, Char DH, Kroll S, Quivey JM, Castro J, Ophthalmology 1997 Nov 104 11 1785-92; discussion 1792-3 -
Langerhans cell histiocytosis diagnosed by fine needle biopsy.
Harbour JW, Char DH, Ljung BM, Luna-Fineman S, Archives of ophthalmology (Chicago, Ill. : 1960) 1997 Sep 115 9 1212-3 -
Pars plana vitrectomy in the management of phakic and pseudophakic malignant glaucoma.
Harbour JW, Rubsamen PE, Palmberg P, Archives of ophthalmology (Chicago, Ill. : 1960) 1996 Sep 114 9 1073-8 -
Local carboplatin therapy in transgenic murine retinoblastoma.
Harbour JW, Murray TG, Hamasaki D, Cicciarelli N, Hernández E, Smith B, Windle J, O'Brien JM, Investigative ophthalmology & visual science 1996 Aug 37 9 1892-8 -
Vitrectomy for diabetic macular edema associated with a thickened and taut posterior hyaloid membrane.
Harbour JW, Smiddy WE, Flynn HW, Rubsamen PE, American journal of ophthalmology 1996 Apr 121 4 405-13 -
Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma.
Harbour JW, Murray TG, Byrne SF, Hughes JR, Gendron EK, Ehlies FJ, Markoe AM, Retina (Philadelphia, Pa.) 1996 16 2 129-34 -
Initial management and follow-up of melanocytic iris tumors.
Harbour JW, Augsburger JJ, Eagle RC, Ophthalmology 1995 Dec 102 12 1987-93 -
Pars plana vitrectomy for chronic pseudophakic cystoid macular edema.
Harbour JW, Smiddy WE, Rubsamen PE, Murray TG, Davis JL, Flynn HW, American journal of ophthalmology 1995 Sep 120 3 302-7 -
Uveal metastasis from carcinoid tumor. Clinical observations in nine cases.
Harbour JW, De Potter P, Shields CL, Shields JA, Ophthalmology 1994 Jun 101 6 1084-90 -
Clivus chordoma: a report of 12 recent cases and review of the literature.
Harbour JW, Lawton MT, Criscuolo GR, Holliday MJ, Mattox DE, Long DM, Skull base surgery 1991 1 4 200-6 -
Expression in lung cancer of a transcribed sequence at the DNF15S2 locus at chromosome 3P21.
Harbour JW, Lai SL, Gazdar AF, Minna JD, Kaye FJ, Anticancer research 1990 Jan-Feb 10 1 23-7 -
Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers.
Leduc F, Brauch H, Hajj C, Dobrovic A, Kaye F, Gazdar A, Harbour JW, Pettengill OS, Sorenson GD, van den Berg A, American journal of human genetics 1989 Feb 44 2 282-7 -
Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.
Harbour JW, Lai SL, Whang-Peng J, Gazdar AF, Minna JD, Kaye FJ, Science (New York, N.Y.) 1988 Jul 241 4863 353-7
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PRAME induces genomic instability in uveal melanoma.
Research
- Genetics and genomics of ocular cancer
- Prognostic biomarkers for ocular cancer
- Mechanisms of metastasis in ocular cancer
- Molecular targeted therapies for ocular cancer
Clinical Focus
- Ocular oncology
- Retinoblastoma
- Uveal melanoma
- Ocular Lymphoma
Articles by Dr. Harbour
Results: 1 Locations
Ophthalmology Clinic
at James W. Aston Ambulatory Care Center 5303 Harry Hines Blvd., 6th FloorDallas, Texas 75390 214-645-2020 Monday-Friday: 7 a.m. to 6 p.m. Directions to Ophthalmology Clinic Parking Info for Ophthalmology Clinic