Pradeep Mammen, M.D.

Internal Medicine - Cardiology
Cardiomyopathies
Heart Failure & Cardiac Support

Biography

Pradeep Mammen, M.D., is a Professor in the Department of Internal Medicine’s Division of Cardiology at UT Southwestern Medical Center.

Dr. Mammen’s clinical and investigative focus is heart failure/heart transplantation, and he serves as Medical Director of the Neuromuscular Cardiomyopathy Clinic, as well as Director of Translational Research for the Advanced Heart Failure and Transplant Cardiology Program.

He is also a member of the UT Southwestern Hamon Center for Regenerative Science & Medicine and runs a molecular laboratory that is funded through grants from the National Institutes of Health and the American Heart Association. Dr. Mammen’s scientific interests revolve around the molecular mechanisms underlying heart failure and he oversees a laboratory dedicated to better understanding this disease entity. The goal is to eventually develop new, targeted heart failure therapies.

After earning his medical degree at the University of Wisconsin School of Medicine, he completed an internal medicine internship and residency at the University of Iowa Hospitals and Clinics, followed by fellowships in cardiology, heart failure/cardiac transplantation, and molecular cardiology at UT Southwestern.

A Fellow of both the American Heart Association and the American College of Cardiology, Dr. Mammen is board certified in internal medicine and cardiovascular medicine. He is one of only 500 U.S. cardiologists board certified in advanced heart failure/transplant cardiology.

Dr. Mammen has published more than 40 journal articles and delivered a number of invited lectures. He has served as a reviewer for publications that include the American Heart Journal, American Journal of Cardiology, American Journal of Physiology–Heart and Circulatory Physiology, Circulation: Heart Failure, Journal of the American College of Cardiology, and the Journal of Cardiac Failure. In addition, Dr. Mammen serves on the Scientific Review Committee for various study sections for the National Institutes of Health and the American Heart Association.

He is a member of professional organizations that include the American College of Cardiology (Heart Failure/VAD/Heart Transplantation Section), American Heart Association (Council on Basic Cardiovascular Sciences as well as the Council on Clinical Cardiology), Heart Failure Society of America, International Society of Heart and Lung Transplantation, and American College of Physicians.

Dr. Mammen also serves as a member of UT Southwestern’s Class of 2013 LEAD Program. He was among 30 faculty members identified as having leadership potential and chosen by the Dean’s Office to take part in a leadership-training program for junior faculty members.

Personal Note

Dr. Mammen and his wife have a son and a daughter.

Meet Dr. Mammen

Heart Failure Specialist

Pradeep Mammen, M.D., finds great satisfaction in his dual role as a clinician-scientist at UT Southwestern Medical Center: As a clinician, he contributes directly to his patients’ health in the clinic, and as a scientist, he pioneers new treatments in the research lab.

Dr. Mammen is an expert in advanced heart failure, ventricular assist devices (VADs), and heart transplantation. He has a special interest in neuromuscular cardiomyopathy – heart failure caused by neuromuscular disorders – and he serves as the Medical Director of UT Southwestern’s dedicated Neuromuscular Cardiomyopathy Clinic, which he founded in 2010. It remains one of only a handful of dedicated neuromuscular cardiomyopathy clinics in the United States.

Meanwhile, Dr. Mammen is one of only 500 cardiologists in the nation who is board certified in advanced heart failure/transplant cardiology. He also performs cardiopulmonary stress testing – a specialized test for advanced heart failure – as well as procedures such as heart biopsies and cardiac catheterizations.

On the research side, Dr. Mammen is the Director of Translational Research for the Advanced Heart Failure Program and investigates the molecular mechanisms underlying heart failure. The goal of his molecular cardiology laboratory is to develop novel therapeutic approaches for the treatment of patients with heart failure. Dr. Mammen’s laboratory is funded through grants from the National Institute of Health and the American Heart Association.

He is optimistic about the future of heart-failure treatment.

“Heart failure, ventricular assist devices, and cardiac transplantation are some of the fastest-growing subspecialties within cardiology,” he says. “And fields like regenerative biology and stem-cell transplantation are enabling us to look at ways to regenerate heart tissue – which helps damaged hearts repair themselves.”

Dr. Mammen is also proud to belong to UT Southwestern’s group of experienced and skilled specialists, a team that includes physicians and surgeons as well as clinicians such as nurse coordinators and practitioners.

“Everything the heart failure/transplant team does, we do as a team – not as individuals – and our patients really benefit from that,” Dr. Mammen says. “UT Southwestern wouldn’t have the excellent heart transplantation survival rates it does if it weren’t for this well-oiled machine, and I’m proud that as a group, we’re able to give these very sick patients another chance at life.”

Education & Training

Undergraduate - University of Pennsylvania, Biomedical Engineering
Medical School - Univ. of Wisconsin-Madison, Medicine

Professional Associations & Affiliations

Texas Medical Association (2004), Member
International Society of Heart and Lung Transplantation (2004), Member
Heart Failure Society of America (2004), Member
Dallas County Medical Society (2004), Member
American Heart Association (2004), Fellow
American College of Physicians (2004), Member
American College of Cardiology (2004), Fellow
Central Society for Clinical Research (2008), Member
American Society for Biochemistry and Molecular Biology (2008), Member

Honors & Awards

Ernest O. Theilen Award 1998, Outstanding Cardiac Care Unit Resident of the Year (U. of Iowa Hospitals & Clinics)
Diplomate in Internal Medicine (American Board of Internal Medicine) 1998
Above and Beyond the Call of Duty Award 1998, Recognition for compassionate care (U. of Iowa Hospitals & Clinics)
Diplomate in Cardiovascular Medicine (American Board of Internal Medicine) 2002
3rd Place: Basic Science Research at the Young Investigators Molecular Cardiovascular Forum: Pathways to Cardiac Development and Regeneration (Sponsored by UT Southwestern Medical Center) 2003
Recipient of the Dr. Madhukar Deshmukh Award (Sponsored by the American Association of Cardiologists of Indian Origin) 2004
Finalist: AstraZeneca Cardiovascular Young Investigators Forum 2004
Recipient of a NIH Clinician Scientist Development Award 2005-2011
Induction as a Fellow into the American College of Cardiology 2005
GlaxoSmithKline Competitive Grant Award for Young Investigators 2005, One of four cardiovascular investigators in the nation to receive this competitive grant.
Finalist: Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators Forum 2005, Outstanding research as a cardiology fellow
2nd Place, Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators’ Forum 2006, Outstanding research as a junior faculty member
Recipient of a AHA Grant-in-Aid Award 2009-2012
Mentor to Sarvjeet Singh PhD, recipient of an AHA Postdoctoral Research Award 2009-2012
Postdoctoral Mentor to Sarvjeet Singh, PhD, a Finalist for the Louis N. and Arnold M. Katz Basic Science Research Award 2010, Highest basic science award given to a junior investigator. The award is sponsored by the American Heart Association
Diplomate in Advanced Heart Failure/Transplant Cardiology (American Board of Internal Medicine) 2010
Mentor to Diana Canseco PhD, recipient of an AHA Postdoctoral Research Award 2011-2013
Induction as a Fellow into the American Heart Association (Council on Basic Cardiovascular Sciences) 2011
Recipient of a NIH-NHLBI R01 Research Grant 2012-2017
UTSW Leadership Emerging in Academic Departments (LEAD) Program (Class of 2013) 2013-2013, Only 30 out of 100 UTSW faculty members were chosen to enter the Class of 2013 based on their future leadership potential.

Books & Publications

Books
- Molecular insights into the functional role of myoglobin. in Hypoxia and the Circulation
  Garry, D.J. and P.P.A. Mammen (2007), Springer
Publications
- Human Ventricular Unloading Induces Cardiomyocyte Proliferation.
  Canseco DC, Kimura W, Garg S, Mukherjee S, Bhattacharya S, Abdisalaam S, Das S, Asaithamby A, Mammen PP, Sadek HA Journal of the American College of Cardiology 2015 Jan
- Variation of heart transplant rates in the united states during holidays.
  Grodin JL, Ayers CR, Thibodeau JT, Mishkin JD, Mammen PP, Markham DW, Drazner MH, Patel PC Clinical transplantation 2014 Jun
- A Sensitive Cardiac Troponin I Assay to Screen for Acute Rejection in Heart Transplant Patients.
  Patel PC, Hill DA, Ayers CR, Kaiser P, Lavingia B, Dyer AK, Barnes AP, Thibodeau JT, Mishkin JD, Mammen PP, Markham DW, Stastny P, Ring WS, de Lemos JA, Drazner MH Circulation. Heart failure 2014 Apr
- Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway.
  Wang ZV, Deng Y, Gao N, Pedrozo Z, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang N, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen PP, Ferdous A, Gillette TG, Scherer PE, Hill JA Cell 2014 Mar 156 6 1179-92
- Characterization of a novel symptom of advanced heart failure: bendopnea.
  Thibodeau JT, Turer AT, Gualano SK, Ayers CR, Velez-Martinez M, Mishkin JD, Patel PC, Mammen PP, Markham DW, Levine BD, Drazner MH JACC. Heart failure 2014 Feb 2 1 24-31
- Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration.
  Singh S, Canseco DC, Manda SM, Shelton JM, Chirumamilla RR, Goetsch SC, Ye Q, Gerard RD, Schneider JW, Richardson JA, Rothermel BA, Mammen PP Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 111 1 E129-38
- Tolerability of sirolimus: a decade of experience at a single cardiac transplant center.
  Thibodeau JT, Mishkin JD, Patel PC, Kaiser PA, Ayers CR, Mammen PP, Markham DW, Ring WS, Peltz M, Drazner MH Clinical transplantation 2013 Nov-Dec 27 6 945-52
- Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease.
  Hunt JM, Bethea B, Liu X, Gandjeva A, Mammen PP, Stacher E, Gandjeva MR, Parish E, Perez M, Smith L, Graham BB, Kuebler WM, Tuder RM American journal of physiology. Lung cellular and molecular physiology 2013 Sep
- Relationship of Right- to Left-Ventricular Filling Pressures in Advanced Heart Failure: Insights from the ESCAPE Trial.
  Drazner MH, Velez-Martinez M, Ayers C, Reimold SC, Thibodeau JT, Mishkin JD, Mammen PP, Markham DW, Patel CB Circulation. Heart failure 2013 Feb
- Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance.
  Quintens R, Singh S, Lemaire K, De Bock K, Granvik M, Schraenen A, Vroegrijk IO, Costa V, Van Noten P, Lambrechts D, Lehnert S, Van Lommel L, Thorrez L, De Faudeur G, Romijn JA, Shelton JM, Scorrano L, Lijnen HR, Voshol PJ, Carmeliet P, Mammen PP, Schuit F PloS one 2013 8 2 e56719
- Health insurance as a requirement to undergo cardiac transplantation: a national survey of transplant program practices.
  Thibodeau JT, Rao MP, Gupta C, Ayers CR, Gupta S, Mammen PP, Markham DW, Mishkin JD, Patel PC, King LP, Drazner MH Transplantation proceedings 2013 Jan 45 1 360-3
- Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family.
  Porrello ER, Mahmoud AI, Simpson E, Johnson BA, Grinsfelder D, Canseco D, Mammen PP, Rothermel BA, Olson EN, Sadek HA Proceedings of the National Academy of Sciences of the United States of America 2013 Jan 110 1 187-92
- Sirolimus use and incidence of venous thromboembolism in cardiac transplant recipients.
  Thibodeau JT, Mishkin JD, Patel PC, Kaiser PA, Ayers CR, Mammen PP, Markham DW, Ring WS, Peltz M, Drazner MH Clinical transplantation 2012 Nov 26 6 953-9
- The natural history of new-onset heart failure with a severely depressed left ventricular ejection fraction: implications for timing of implantable cardioverter-defibrillator implantation.
  Teeter WA, Thibodeau JT, Rao K, Brickner ME, Toto KH, Nelson LL, Mishkin JD, Ayers CR, Miller JG, Mammen PP, Patel PC, Markham DW, Drazner MH American heart journal 2012 Sep 164 3 358-64
- IIIB or not IIIB: a previously unanswered question.
  Thibodeau JT, Mishkin JD, Patel PC, Mammen PP, Markham DW, Drazner MH Journal of cardiac failure 2012 May 18 5 367-72
- Utilization of cardiac computed tomography angiography for the diagnosis of left ventricular assist device thrombosis.
  Mishkin JD, Enriquez JR, Meyer DM, Bethea BT, Thibodeau JT, Patel PC, Markham DW, Mammen PP, Velez-Martinez M, Drazner MH Circulation. Heart failure 2012 Mar 5 2 e27-9
- Successful use of the TandemHeart percutaneous ventricular assist device as a bridge to recovery for acute cellular rejection in a cardiac transplant patient.
  Velez-Martinez M, Rao K, Warner J, Dimaio J, Ewing G, Mishkin JD, Mammen PP, Drazner MH, Markham DW, Patel PC Transplantation proceedings 2011 Dec 43 10 3882-4
- Concentric left ventricular hypertrophy as assessed by cardiac magnetic resonance imaging and risk of death in cardiac transplant recipients.
  Patel PC, Reimold SC, Araj FG, Ayers CR, Kaiser PA, Peshock RM, Yancy CW, Ring WS, Gupta S, Mishkin JD, Mammen PP, Markham DW, Drazner MH The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010 Dec 29 12 1369-79
- Regulation of myoglobin expression.
  Kanatous SB, Mammen PP The Journal of experimental biology 2010 Aug 213 Pt 16 2741-7
- Clinical outcomes after cardiac transplantation in muscular dystrophy patients.
  Wu RS, Gupta S, Brown RN, Yancy CW, Wald JW, Kaiser P, Kirklin NM, Patel PC, Markham DW, Drazner MH, Garry DJ, Mammen PP The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010 Apr 29 4 432-8
- Pancreatic gout masquerading as pancreatic cancer in a heart transplant candidate.
  Gupta S, McMahan Z, Patel PC, Markham DW, Drazner MH, Mammen PP The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2009 Oct 28 10 1112-3
- Utility of routine immunofluorescence staining for C4d in cardiac transplant recipients.
  Gupta S, Mitchell JD, Lavingia B, Ewing GE, Feliciano MN, Kaiser PA, Ring WS, Stastny P, Patel PC, Markham DW, Mammen PP, Dimaio JM, Drazner MH The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2009 Aug 28 8 776-80
- Calcineurin activates cytoglobin transcription in hypoxic myocytes.
  Singh S, Manda SM, Sikder D, Birrer MJ, Rothermel BA, Garry DJ, Mammen PP The Journal of biological chemistry 2009 Apr 284 16 10409-21
- Hypoxia reprograms calcium signaling and regulates myoglobin expression.
  Kanatous SB, Mammen PP, Rosenberg PB, Martin CM, White MD, Dimaio JM, Huang G, Muallem S, Garry DJ American journal of physiology. Cell physiology 2009 Mar 296 3 C393-402
- Association of cystatin C with left ventricular structure and function: the Dallas Heart Study.
  Patel PC, Ayers CR, Murphy SA, Peshock R, Khera A, de Lemos JA, Balko JA, Gupta S, Mammen PP, Drazner MH, Markham DW Circulation. Heart failure 2009 Mar 2 2 98-104
- Association of Cystatin C with left ventricular structure and function: The Dallas Heart Study.
  Patel, P.C., S.A. Murphy, R. Peshock, A. Khera, J.A. de Lemos, J.A. Balko, S Gupta, P.P.A. Mammen, M.H. Drazner, and D.W. Markham. Circulation-Heart Failure February 2009 In Press Online February 10, 2009
- Calcineurin activates cytoglobin transcription in hypoxic myocytes.
  Singh S.*, S.M. Manda*, D. Sikder, M.J. Birrer, B.A. Rothermel, D.J. Garry, and P.P.A. Mammen. Journal of Biological Chemistry February 2009 In Press Online February 9, 2009
- Hypoxia reprograms calcium signaling and regulates myoglobin expression.
  Kanatous, S.B., P.P.A. Mammen, P.B. Rosenberg, C.M. Martin, M.D. White, J.M. DiMaio, G Huang, S. Muallem, and D.J. Garry American Journal of Physiology - Cell Physiology November 2008 In Press Presently online
- Fulminant myocarditis.
  Gupta S, Markham DW, Drazner MH, Mammen PP Nature clinical practice. Cardiovascular medicine 2008 Nov 5 11 693-706
- Utility of the Cylex assay in cardiac transplant recipients.
  Gupta S, Mitchell JD, Markham DW, Mammen PP, Patel PC, Kaiser PA, Stastny P, Ring WS, Dimaio JM, Drazner MH The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008 Aug 27 8 817-22
- High incidence of cytomegalovirus disease in D+/R- heart transplant recipients shortly after completion of 3 months of valganciclovir prophylaxis.
  Gupta S, Mitchell JD, Markham DW, Mammen PP, Patel PC, Kaiser P, Ring WS, DiMaio JM, Drazner MH The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008 May 27 5 536-9
- Long-term follow-up of a heart transplant recipient with documented seroconversion to HIV-positive status 1 year after transplant.
  Gupta S, Markham DW, Mammen PP, Kaiser P, Patel P, Ring WS, Drazner MH American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008 Apr 8 4 893-6
- Fulminant myocarditis.
  Gupta S., D.W. Markham, M.H. Drazner, and P.P.A. Mammen Nature Clinical Practice Cardiovascular Medicine 2008 5(11) 693-706
- Molecular insights into the functional role of myoglobin.
  Garry DJ, Mammen PP Advances in experimental medicine and biology 2007 618 181-93
- Cytoglobin is a stress-responsive hemoprotein expressed in the developing and adult brain.
  Mammen PP, Shelton JM, Ye Q, Kanatous SB, McGrath AJ, Richardson JA, Garry DJ The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006 Dec 54 12 1349-61
- Cytoglobin: A novel stress-responsive hemoprotein that is expressed in the developing and adult brain.
  Mammen P.P.A., J.M Shelton, Q. Ye, S.B. Kanatous, A.J. McGrath, J.A. Richardson, and D.J. Garry Journal of Histochemistry & Cytochemistry 2006 54(12) 1349-1361
- Alternative therapies for orthotopic heart transplantation.
  Garry DJ, Goetsch SC, McGrath AJ, Mammen PP The American journal of the medical sciences 2005 Aug 330 2 88-101
- LXRs regulate the balance between fat storage and oxidation.
  Kalaany NY, Gauthier KC, Zavacki AM, Mammen PP, Kitazume T, Peterson JA, Horton JD, Garry DJ, Bianco AC, Mangelsdorf DJ Cell metabolism 2005 Apr 1 4 231-44
- The capsaicin-sensitive afferent neuron in skeletal muscle is abnormal in heart failure.
  Smith SA, Williams MA, Mitchell JH, Mammen PP, Garry MG Circulation 2005 Apr 111 16 2056-65
- LXRs: Double agents in the regulation of dietary fat and cholesterol metabolism.
  Kalaany N.Y, K.C. Gauthier, A.M. Zavacki, P.P.A. Mammen, T. Kitazume, J.A. Peterson, D.J. Garry, A.C. Bianco, and D.J. Mangelsdorf. Cell Metabolism 2005 1 231-244
- Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice.
  Mammen PP, Kanatous SB, Yuhanna IS, Shaul PW, Garry MG, Balaban RS, Garry DJ American journal of physiology. Heart and circulatory physiology 2003 Nov 285 5 H2132-41
- Role of the exercise pressor reflex in rats with dilated cardiomyopathy.
  Smith SA, Mammen PP, Mitchell JH, Garry MG Circulation 2003 Sep 108 9 1126-32
- Neuroprotection and the role of neuroglobin.
  Garry DJ, Mammen PP Lancet 2003 Aug 362 9381 342-3
- Emerging roles for myoglobin in the heart.
  Garry DJ, Kanatous SB, Mammen PP Trends in cardiovascular medicine 2003 Apr 13 3 111-6
- Hypoxia-induced left ventricular dysfunction in myoglobin deficient mice.
  Mammen P.P.A., S.B. Kanatous, I. Yuhanna, P. W. Shaul, R.S. Balaban, M.G. Garry, and D.J. Garry Am J Physiol: Heart and Circulatory Physiology 2003 285 H2132-2141
- Emerging roles of myoglobin in the heart.
  Garry D.J., S.B. Kanatous, and P.P.A. Mammen Trends in Cardiovascular Medicine 2003 13 111-116
- Neuroglobin, a novel member of the globin family, is expressed in focal regions of the brain.
  Mammen PP, Shelton JM, Goetsch SC, Williams SC, Richardson JA, Garry MG, Garry DJ The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002 Dec 50 12 1591-8
- Adaptive mechanisms that preserve cardiac function in mice without myoglobin.
  Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ Circulation research 2001 Apr 88 7 713-20
- Adaptive mechanisms that preserve cardiac function in mice without myoglobin.
  Meeson A., N. Radford, J.M. Shelton, P.P.A. Mammen, Y.Kong, J.M. DiMaio, K. Hutcheson, J. Elterman, R.S. Williams, and D.J. Garry Circulation Research 2001 88 713-720
- Myocyte-enriched calcineurin interacting protein, MCIP1, inhibits cardiac hypertrophy.
  Rothermel B.A., T.A. McKinsey, R.B. Vega, R.L.Nicol, P. Mammen, J. Yang, C. Antos, J.M. Shelton, R. Bassel-Duby, E.N. Olson, and R.S. Williams. Proceedings of the National Academy of Sciences USA 2001 98 3328-3333
- Isometric and dynamic contractile properties of porcine skinned cardiac myocytes after stunning.
  McDonald KS, Mammen PP, Strang KT, Moss RL, Miller WP Circulation research 1995 Nov 77 5 964-72