- Residency - Children's Hospital of Philadelphia (2000-2005), Pediatrics & Medical Genetics
- Medical School - University of Pennsylvania School of Medicine (1992-2000)
Ralph DeBerardinis, M.D., Ph.D.
Chief, Division of Pediatric Genetics and Metabolism
- Sowell Family Scholar in Medical Research
- Joel B. Steinberg, M.D. Distinguished Chair in Pediatrics
- Pediatrics - Genetics and Metabolism
Ralph DeBerardinis earned a B.S. in biology from St. Joseph’s University and M.D. and Ph.D. degrees from the University of Pennsylvania. Dr. DeBerardinis was the first trainee in the combined residency program in pediatrics and medical genetics at The Children’s Hospital of Philadelphia (CHOP) and received several awards for teaching and clinical care. He ultimately achieved board certification in pediatrics, medical genetics and clinical biochemical genetics.
Dr. DeBerardinis performed postdoctoral research in Craig Thompson’s laboratory in the Penn Cancer Center from 2004 to 2007. He joined the faculty of the University of Texas Southwestern Medical Center in 2008 and joined the Children’s Medical Center Research Institute at UT Southwestern (CRI) shortly after its founding in 2012. Dr. DeBerardinis serves as chief of Pediatric Genetics and Metabolism at UT Southwestern and director of the Genetic and Metabolic Disease Program in the CRI.
He was included in D Magazine's Best Doctors list for 2018, 2020, and 2021.
About His Laboratory
The DeBerardinis laboratory is interested in the role of altered metabolic states in human diseases, particularly pediatric inborn errors of metabolism and cancer. This research is tightly integrated with clinical activities in medical genetics, oncology and radiology, providing seamless opportunities to examine the relevance of findings in patients.
Education & Training
Professional Associations & Affiliations
- Investigator, Howard Hughes Medical Institute (2018)
- Society for Pediatrics Research
- Society for Inherited Metabolic Disorders
- American Society of Human Genetics
- American Association for Cancer Research
- American Academy of Pediatrics
- American Society for Clinical Investigation
Honors & Awards
- D Magazine Best Pediatric Specialist 2020-2021
- Edith and Peter O’Donnell Award in Medicine, The Academy of Medicine, Engineering, and Science of Texas 2018
- Robert L. Moody, Sr. Faculty Scholar 2017
- Howard Hughes Medical Institute Faculty Scholar 2017
- NCI Outstanding Investigator 2017
- American Society for Clinical Investigation
- CHOP Pediatric Scholars Program & Faculty Honor Roll 2007
- William K. Bowes, Jr. Award in Medical Genetics 2008
- Sowell Family Scholar in Medical Research 2008
- Soc. for Inherited Metabolic Disorders Neil Buist Award 2008
- President’s Research Council Distinguished Young Researcher Award 2008
- Damon Runyon Cancer Research Foundation Clinical Investigator Award 2011
Books & Publications
The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.
Shi X, Tasdogan A, Huang F, Hu Z, Morrison SJ, DeBerardinis RJ Science advances 2017 Nov 3 11 eaao5268
Genomic regression analysis of coordinated expression.
Cai L, Li Q, Du Y, Yun J, Xie Y, DeBerardinis RJ, Xiao G Nature communications 2017 Dec 8 1 2187
Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein.
Jiang L, Boufersaoui A, Yang C, Ko B, Rakheja D, Guevara G, Hu Z, DeBerardinis RJ Metabolic engineering 2016 Nov
Metabolic Heterogeneity in Human Lung Tumors.
Hensley CT, Faubert B, Yuan Q, Lev-Cohain N, Jin E, Kim J, Jiang L, Ko B, Skelton R, Loudat L, Wodzak M, Klimko C, McMillan E, Butt Y, Ni M, Oliver D, Torrealba J, Malloy CR, Kernstine K, Lenkinski RE, DeBerardinis RJ Cell 2016 Feb 164 4 681-94
Reductive carboxylation supports growth in tumour cells with defective mitochondria.
Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, Deberardinis RJ Nature 2011 Nov
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB Proceedings of the National Academy of Sciences of the United States of America 2007 Dec 104 49 19345-50
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ Nature 2017 Jun 546 7656 168-172
Reductive carboxylation supports redox homeostasis during anchorage-independent growth.
Jiang L, Shestov AA, Swain P, Yang C, Parker SJ, Wang QA, Terada LS, Adams ND, McCabe MT, Pietrak B, Schmidt S, Metallo CM, Dranka BP, Schwartz B, DeBerardinis RJ Nature 2016 Apr 532 7598 255-8
Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.
Yang C, Ko B, Hensley CT, Jiang L, Wasti AT, Kim J, Sudderth J, Calvaruso MA, Lumata L, Mitsche M, Rutter J, Merritt ME, DeBerardinis RJ Molecular cell 2014 Nov 56 3 414-24
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.
Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, Deberardinis RJ, Lavker RM, Chandel NS Science signaling 2013 6 261 ra8
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CR, Bachoo RM, Maher EA Nature medicine 2012 Apr 18 4 624-9
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB Cell metabolism 2008 Jan 7 1 11-20
Lactate Metabolism in Human Lung Tumors.
Faubert B, Li KY, Cai L, Hensley CT, Kim J, Zacharias LG, Yang C, Do QN, Doucette S, Burguete D, Li H, Huet G, Yuan Q, Wigal T, Butt Y, Ni M, Torrealba J, Oliver D, Lenkinski RE, Malloy CR, Wachsmann JW, Young JD, Kernstine K, DeBerardinis RJ Cell 2017 Oct 171 2 358-371.e9
Understanding the Intersections between Metabolism and Cancer Biology.
Vander Heiden MG, DeBerardinis RJ Cell 2017 Feb 168 4 657-669
Cellular metabolism and disease: what do metabolic outliers teach us?
DeBerardinis RJ, Thompson CB Cell 2012 Mar 148 6 1132-44
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.
Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, Deberardinis RJ, Bachoo RM Cell metabolism 2012 Jun 15 6 827-37
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells.
Cheng T, Sudderth J, Yang C, Mullen AR, Jin ES, Matés JM, DeBerardinis RJ Proceedings of the National Academy of Sciences of the United States of America 2011 May 108 21 8674-9
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ Cell metabolism 2018 Jun
Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer.
Kim HS, Mendiratta S, Kim J, Pecot CV, Larsen JE, Zubovych I, Seo BY, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs JE, Wei S, Peyton M, Williams N, Gazdar AF, Posner BA, Brekken RA, Sood AK, Deberardinis RJ, Roth MG, Minna JD, White MA Cell 2013 Oct 155 3 552-66
Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects.
Mullen AR, Hu Z, Shi X, Jiang L, Boroughs LK, Kovacs Z, Boriack R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS, DeBerardinis RJ Cell reports 2014 May
Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells.
Rajagopalan KN, Egnatchik RA, Calvaruso MA, Wasti AT, Padanad MS, Boroughs LK, Ko B, Hensley CT, Acar M, Hu Z, Jiang L, Pascual JM, Scaglioni PP, DeBerardinis RJ Cancer & metabolism 2015 3 7
Metabolic pathways promoting cancer cell survival and growth.
Boroughs LK, DeBerardinis RJ Nature cell biology 2015 Apr 17 4 351-359
Fundamentals of cancer metabolism.
DeBerardinis RJ, Chandel NS Science advances 2016 May 2 5 e1600200
Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans.
Ni M, Solmonson A, Pan C, Yang C, Li D, Notzon A, Cai L, Guevara G, Zacharias LG, Faubert B, Vu HS, Jiang L, Ko B, Morales NM, Pei J, Vale G, Rakheja D, Grishin NV, McDonald JG, Gotway GK, McNutt MC, Pascual JM, DeBerardinis RJ, Cell reports 2019 Apr 27 5 1376-1386.e6
Mechanisms and Implications of Metabolic Heterogeneity in Cancer.
Kim J, DeBerardinis RJ, Cell metabolism 2019 Sep 30 3 434-446
Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo.
Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo RM, Maher EA Cell metabolism 2018 Aug
Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.
Chen PH, Cai L, Huffman K, Yang C, Kim J, Faubert B, Boroughs L, Ko B, Sudderth J, McMillan EA, Girard L, Chen D, Peyton M, Shields MD, Yao B, Shames DS, Kim HS, Timmons B, Sekine I, Britt R, Weber S, Byers LA, Heymach JV, Chen J, White MA, Minna JD, Xiao G, DeBerardinis RJ, Molecular cell 2019 Sep
Tumor Microenvironment, Metabolism, and Immunotherapy.
DeBerardinis RJ, The New England journal of medicine 2020 02 382 9 869-871
Metabolic heterogeneity confers differences in melanoma metastatic potential.
Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, Murphy MM, Gu Z, Gu W, Martin M, Kasitinon SY, Vandergriff T, Mathews TP, Zhao Z, Schadendorf D, DeBerardinis RJ, Morrison SJ, Nature 2020 01 577 7788 115-120
- The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.
- Inborn errors of metabolism
- Genetic disorders in children