Rebecca Gruchalla, M.D., Ph.D.

Chief, Division of Pediatric Allergy and Immunology

William A. Sellars, M.D., and Joyce M. Sellars Distinguished Chair in Allergy and Immunology

Internal Medicine - Allergy and Immunology

New Patient Appointment Accepting Virtual Visits or 214-645-8300

Biography

Rebecca S. Gruchalla, M.D., Ph.D., is Professor of Internal Medicine and Pediatrics and Director of the Division of Allergy and Immunology at the University of Texas Southwestern Medical Center at Dallas. She also holds the William A. Sellars M.D. and Joyce M. Sellars Distinguished Chair in Allergy and Immunology.

Dr. Gruchalla received her Ph.D. and medical degrees from UT Southwestern Medical Center at Dallas. After completing internal medicine training at the Hospital of the University of Pennsylvania and allergy and immunology training at UT Southwestern, she joined the UT Southwestern faculty. Dr. Gruchalla conducts clinical research in the area of inner city pediatric asthma and she has been leading NIAID-funded inner city pediatric asthma studies since 1994.

Dr. Gruchalla currently is participating in the multi-site Inner City Asthma Consortium as the Dallas-site director. Dr. Gruchalla is a past member of the Board of Directors of the American Academy of Allergy and Immunology and the Board of Directors of the American Board of Allergy and Immunology.

In 2018, 2020, and 2021, she was included in D Magazine's Best Doctors list and has also been named a Texas Monthly Super Doctor.

Education & Training

Fellowship - UT Southwestern Medical Center (1988-1991), Allergy & Immunology
Residency - Hospital of the University of Pennsylvania (1986-1988), Internal Medicine
Internship - Hospital of the University of Pennsylvania (1985-1986), Internal Medicine
Medical School - UT Southwestern Medical School (1981-1985)

Professional Associations & Affiliations

American Thoracic Society
American Academy of Allergy, Asthma & Immunology

Honors & Awards

D Magazine Best Doctor 2021
D Magazine Best Pediatric Specialist 2020
Texas Super Doctor 2017, Texas Monthly Magazine
Best Doctors in Dallas 2017, D Magazine
Women’s Involvement in the AAAAI 2007, Special Recognition Award
Gail G. Shapiro Memorial Lectureship 2007, Lectureship Award
AAAAI Special Recognition Award 2004, Editorial Award
Aventis/AAAAI Women Physician in Allergy Grant Award 2003, Research Award
Boehringer-Ingelheim AAAI/NIAID 1992, Research Award

Books & Publications

Publications
- The nasal methylome and childhood atopic asthma.
  Yang IV, Pedersen BS, Liu AH, O'Connor GT, Pillai D, Kattan M, Misiak RT, Gruchalla R, Szefler SJ, Khurana Hershey GK, Kercsmar C, Richards A, Stevens AD, Kolakowski CA, Makhija M, Sorkness CA, Krouse RZ, Visness C, Davidson EJ, Hennessy CE, Martin RJ, Togias A, Busse WW, Schwartz DA The Journal of allergy and clinical immunology 2017 May 139 5 1478-1488
- Minimally important differences and risk levels for the Composite Asthma Severity Index.
  Krouse RZ, Sorkness CA, Wildfire JJ, Calatroni A, Gruchalla R, Hershey GKK, Kattan M, Liu AH, Makhija M, Teach SJ, West JB, Wood RA, Zoratti EM, Gergen PJ The Journal of allergy and clinical immunology 2017 Mar 139 3 1052-1055
- Effects of Omalizumab on Rhinovirus Infections, Illnesses and Exacerbations of Asthma.
  Esquivel A, Busse WW, Calatroni A, Togias AG, Grindle KG, Bochkov YA, Gruchalla RS, Kattan M, Kercsmar CM, Khurana Hershey G, Kim H, Lebeau P, Liu AH, Szefler SJ, Teach SJ, West JB, Wildfire J, Pongracic JA, Gern JE American journal of respiratory and critical care medicine 2017 Jun
- Can We Be Too Clean for Our Own Good? The Hygiene Hypothesis Reviewed.
  Patel S, Gruchalla R Texas medicine 2017 Feb 113 2 54-59
- Can We Predict Fall Asthma Exacerbations? Validation Of The Seasonal Asthma Exacerbation Index.
  Hoch HE, Calatroni A, West JB, Liu AH, Gergen PJ, Gruchalla RS, Hershey KG, Kercsmar CM, Kim H, Lamm CI, Makhija MM, Mitchell HE, Teach SJ, Wildfire JJ, Busse WW, Szefler SJ The Journal of allergy and clinical immunology 2017 Feb
- Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children.
  Busse WW, Morgan WJ, Gergen PJ, Mitchell HE, Gern JE, Liu AH, Gruchalla RS, Kattan M, Teach SJ, Pongracic JA, Chmiel JF, Steinbach SF, Calatroni A, Togias A, Thompson KM, Szefler SJ, Sorkness CA The New England journal of medicine 2011 Mar 364 11 1005-15
- Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells.
  Gill MA, Bajwa G, George TA, Dong CC, Dougherty II, Jiang N, Gan VN, Gruchalla RS Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 184 11 5999-6006
- Preventing peanut allergy through early consumption--ready for prime time?
  Gruchalla RS, Sampson HA The New England journal of medicine 2015 Feb 372 9 875-7
- Lack of penicillin resensitization in patients with a history of penicillin allergy
  Solensky R, Earl HS, Gruchalla RS. Archives of Internal Medicine 2002 162 822-826
- The Inner City Asthma Study: A home-based environmental intervention in inner city children with asthma
  Morgan WJ, Crain E, Gruchalla RS, O’Connor G, Kattan M, Evans R, Stout J, Malindzak G, Smartt E, Plaut M, Walter M, Vaughn B, Mitchell H N England Journal of Medicine August 2004 351 1068-80
- Safety of cephalosporin administration to patients with histories of penicillin allergy
  Daulat S, Solensky R, Earl HS, Casey W, Gruchalla J Allergy Clin Immunol June 2004 6/113 1220-1222
- The Inner City Asthma Study: Relationships between sensitivity, exposure and morbidity
  Gruchalla RS, Pongracic J, Plaut M, Evans R, Visness CM, Walter M, Crain EF, Kattan M, Morgan WJ, Steinback S, Stout J, Malindzak G, Smartt E, Mitchell H Journal of Allergy and Clinical Immunology March 2005 115 584-91
- The Inner City Asthma Study: Relationships between sensitivity, exposure and morbidity
  Gruchalla RS, Pongracic J, Plaut M, Evans R, Visness CM, Walter M, Crain EF, Kattan M, Morgan WJ, Steinback S, Stout J, Malindzak G, Smartt E, Mitchell H Journal of Allergy and Clinical Immunology March 2005 115 584-91
- Home and allergic characteristics of children with asthma in seven US urban communities and design of an environmental intervention: the Inner-City Asthma Study
  Crain EF, Walter, M, O’Conner GT, Mitchell H, Gruchalla RS, Kattan M, Malindzak GS, Enright P, Evans R 3rd, Morgan W, Stout JW Environ Health Perspect September 2002 9/110 939-945
- Management of asthma based on exhaled nitric oxide in addition to guidelines-based treatment for inner-city adolescents and young adults: a randomized controlled trial
  Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O’Connor GT, Morgan WJ, Kattan M, Pongracic JA, Teach SA, Bloomberg GR, Eggleston PA, Gruchalla RS, Kercsmar CM, Liu AH, Wildfire JJ, Curry MD, Busse WW Lancet 2008 372 (9643) 1065-72
- Management of asthma based on exhaled nitric oxide in addition to guidelines-based treatment for inner-city adolescents and young adults: a randomized controlled trial
  Szefler AJ, Mitchell H, Sorkness CA, Gergen PJ, O’Connor GT, Morgan WJ, Kattan M, Pongracic JA, Teach SA, Bloomberg GR, Eggleston PA, Gruchalla RS, Kercsmar CM, Liu AH, Wildfire JJ, Curry MD, Busse WW Lancet 2008 372 (9643) 1065-72
- Drug metabolism, danger signals and drug hypersensitivity
  Gruchalla RS J Allergy Clin Immunol 2001 108 475-478
- IgE cross-linking critically impairs human monocyte function by blocking phagocytosis.
  Pyle DM, Yang VS, Gruchalla RS, Farrar JD, Gill MA The Journal of allergy and clinical immunology 2013 Feb 131 2 491-500.e5
- Clinical evaluation of drug-induced disease
  Gruchalla RS Lancet 2000 356 1505-1511
- Rhinitis in Children and Adolescents with Asthma: Ubiquitous, Difficult to Control, and Associated with Asthma Outcomes.
  Togias A, Gergen PJ, Hu JW, Babineau DC, Wood RA, Cohen RT, Makhija MM, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Liu AH, Wang E, Kim H, Lamm CI, Bacherier LB, Pillai D, Sigelman SM, Gern JE, Busse WW The Journal of allergy and clinical immunology 2018 Sep

Research

Pediatric Asthma Clinical Research