- Residency - Sidney Kimmel Medical College at Thomas Jefferson University (2012-2016), Radiation Oncology
- Internship - University of Florida College of Medicine (2011-2012), Internal Medicine
- Medical School - University of Florida College of Medicine (2006-2011)
Tu Dan, M.D.
- Radiation Oncology
- Radiation Therapy for Cancer
- Radiation Therapy for Spinal Cord Cancer
New Patient Appointment Accepting Virtual Visits or 214-645-8525
Biography
Dr. Tu Dan grew up in Florida and graduated cum laude from the University of Florida with degrees in microbiology and psychology; he continued at UF and earned his medical degree with honors in research. During medical school, he spent significant time at the National Institutes of Health developing his interests in cancer research and, between his third and fourth years, was selected to participate in the prestigious NIH Clinical Research Training Program (CRTP).
His interest in research continued as he completed an internship in internal medicine and a residency in radiation oncology at Thomas Jefferson University in Pennsylvania. While in residency, he was awarded a Resident Seed Grant from the American Society of Radiation Oncology (ASTRO) investigating the role of microRNAs in the development of breast cancer. He has been the lead or contributing author of numerous cancer research papers published in peer-reviewed medical journals.
Dr. Dan arrived at UT Southwestern in 2016 and became a member of the dedicated central nervous system (CNS) cancer team focusing on the treatment of adults and children with primary and metastatic brain tumors. He remains active in the laboratory and is interested in utilizing next-generation gene-editing technology (e.g., clustered regularly interspaced short palindromic repeats, or CRISPR ) to investigate novel mediators of radiation sensitivity and resistance under the direction of Howard Hughes Medical Institute investigator Joshua Mendell, M.D., Ph.D.
Despite his transplant to Dallas, Dr. Dan remains loyal to Florida sports and continues to be a lifelong Gators fan. He is a health and fitness advocate who takes a holistic approach to treatment and has published a number of manuscripts examining the role of diet in the development and treatment of cancer. He believes that in addition to standard treatments, other factors including diet, exercise, and psychological well-being all play important roles in the care of cancer patients.
Meet Dr. Dan
Tu Dan, M.D., is a member of the team devoted to treating central nervous system (CNS) malignancies such as brain tumors and cancers of the spinal cord. He is also a committed physician-scientist, devoting a significant portion of his professional time to the study of radiation resistance and strategies to improve the efficacy of radiation.
"When I began studying to become a doctor, I encountered so many uncertainties and shortcomings in our current understanding of cancer,” Dr. Dan says. “I was always questioning why we couldn’t explain why certain tumors behave differently than others. This is what motivated me to pursue a research career – to improve our understanding of cancer so that better treatments for patients can be developed.”
With advanced tools such as CyberKnife and Gamma Knife, Dr. Dan works closely with UT Southwestern’s neurosurgery team to treat both primary and metastatic cancers in the brain and spine. He also has specialized training and experience in treating pediatric patients with cancer.
“Cancer can be a very scary diagnosis; there’s a lot of anxiety involved,” Dr. Dan says. “Cancer is also very complex. It’s important for doctors to use their experience and expertise to distill the information as best as possible so that patients can understand what their treatment options are and best formulate their goals of care.
“My role is to be an advocate and information source so that patients can make the best decisions for themselves.”
Dr. Tu Dan’s clinical interests include:
- Radiation therapy
- Central nervous system (CNS) malignancies
- Pediatric cancer
Education & Training
Honors & Awards
- Texas Super Doctors, Rising Star 2021
- Texas Super Doctors, Rising Star 2020
Books & Publications
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Publications
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Where Does Auto-Segmentation for Brain Metastases Radiosurgery Stand Today?
Kim M, Wang JY, Lu W, Jiang H, Stojadinovic S, Wardak Z, Dan T, Timmerman R, Wang L, Chuang C, Szalkowski G, Liu L, Pollom E, Rahimy E, Soltys S, Chen M, Gu X Bioengineering 2024 May 11 -
BIOGUIDE-X: A First-in-Human Study of the Performance of Positron Emission Tomography-Guided Radiation Therapy
Vitzthum LK, Surucu M, Gensheimer MF, Kovalchuk N, Han B, Pham D, Chang D, Shirvani SM, Aksoy D, Maniyedath A, Narayanan M, Da Silva AJ, Mazin S, Feghali KA, Iyengar P, Dan T, Pompos A, Timmerman R, Öz O, Cai B, Garant A International Journal of Radiation Oncology Biology Physics 2024 Apr 118 1172-1180 -
Single-Fraction Versus Fractionated Preoperative Radiosurgery for Resected Brain Metastases: A PROPS-BM International Multicenter Cohort Study
Prabhu RS, Akinyelu T, Vaslow ZK, Matsui JK, Haghighi N, Dan T, Mishra MV, Murphy ES, Boyles S, Perlow HK, Palmer JD, Udovicich C, Patel TR, Wardak Z, Woodworth GF, Ksendzovsky A, Yang K, Chao ST, Asher AL, Burri SH International Journal of Radiation Oncology Biology Physics 2024 Mar 118 650-661 -
Modeling gamma knife radiosurgical toxicity for multiple brain metastases
Hsu EJ, Yan Y, Timmerman RD, Wardak Z, Dan TD, Patel TR, Vo D, Stojadinovic S Radiotherapy and Oncology 2023 Nov 188 -
Risk Factors for Progression and Toxic Effects after Preoperative Stereotactic Radiosurgery for Patients with Resected Brain Metastases
Prabhu RS, Akinyelu T, Vaslow ZK, Matsui JK, Haghighi N, Dan T, Mishra MV, Murphy ES, Boyles S, Perlow HK, Palmer JD, Udovicich C, Patel TR, Wardak Z, Woodworth GF, Ksendzovsky A, Yang K, Chao ST, Asher AL, Burri SH JAMA Oncology 2023 Aug 9 1066-1073 -
Evaluation of fan-beam kilovoltage computed tomography image quality on a novel biological-guided radiotherapy platform
Zhuang T, Gibbard G, Duan X, Tan J, Park Y, Lin MH, Sun Z, Oderinde OM, Lu W, Reynolds Jr. RR, Godley A, Pompos A, Dan T, Garant A, Iyengar P, Timmerman R, Jiang S, Cai B Physics and Imaging in Radiation Oncology 2023 Apr 26 -
Ensemble learning for glioma patients overall survival prediction using pre-operative MRIs
Yang Z, Chen M, Kazemimoghadam M, Ma L, Stojadinovic S, Wardak Z, Timmerman R, Dan T, Lu W, Gu X Physics in medicine and biology 2022 Dec 67 -
Impact of CDKN2A/B, MTAP, and TERT Genetic Alterations on Survival in IDH Wild Type Glioblastomas
Hsu EJ, Thomas J, Maher EA, Youssef M, Timmerman RD, Wardak Z, Dan TD, Patel TR, Vo D Discover Oncology 2022 Dec 13 -
Socioeconomic and demographic determinants of radiation treatment and outcomes in glioblastoma patients
Hsu EJ, Thomas J, Timmerman RD, Wardak Z, Dan TD, Patel TR, Sanford NN, Vo D Frontiers in Neurology 2022 Nov 13 -
Neutrophilia and post-radiation thrombocytopenia predict for poor prognosis in radiation-treated glioma patients
Hsu EJ, Thomas J, Maher EA, Youssef M, Timmerman RD, Wardak Z, Lee M, Dan TD, Patel TR, Vo D Frontiers in Oncology 2022 Sep 12 -
Volumetric Modulated Arc Therapy Enabled Total Body Irradiation (VMAT-TBI): Six-year Clinical Experience and Treatment Outcomes
Zhang-Velten ER, Parsons D, Lee P, Chambers E, Abdulrahman R, Desai NB, Dan T, Wardak Z, Timmerman R, Vusirikala M, Patel PA, Simms-Waldrip T, Aquino V, Koh A, Tan J, Iqbal Z, Zhang Y, Reynolds Jr. RR, Chiu T, Joo M, Hrycushko B, Ouyang L, Lamphier R, Yan Y, Jiang SB, Kumar KA, Gu X Transplantation and Cellular Therapy 2022 Feb 28 113.e1-113.e8 -
Deep-learning and radiomics ensemble classifier for false positive reduction in brain metastases segmentation
Yang Z, Chen M, Kazemimoghadam M, Ma L, Stojadinovic S, Timmerman R, Dan T, Wardak Z, Lu W, Gu X Physics in medicine and biology 2022 Jan 67 -
Preoperative Radiosurgery for Resected Brain Metastases: The PROPS-BM Multicenter Cohort Study
Prabhu RS, Dhakal R, Vaslow ZK, Dan T, Mishra MV, Murphy ES, Patel TR, Asher AL, Yang K, Manning MA, Stern JD, Patel AR, Wardak Z, Woodworth GF, Chao ST, Mohammadi A, Burri SH International Journal of Radiation Oncology Biology Physics 2021 Nov 111 764-772 -
MiR-21 plays a dual role in tumor formation and cytotoxic response in breast tumors
Dan T, Shastri AA, Palagani A, Buraschi S, Neill T, Savage JE, Kapoor A, Deangelis T, Addya S, Camphausen K, Iozzo RV, Simone NL Cancers 2021 Feb 13 1-16 -
Phase II trial of hippocampal-sparing whole brain irradiation with simultaneous integrated boost for metastatic cancer
Westover KD, Travis Mendel J, Dan T, Kumar K, Gao A, Pulipparacharuv S, Iyengar P, Nedzi L, Hannan R, Anderson J, Choe KS, Jiang W, Abdulrahman R, Rahimi A, Folkert M, Laine A, Presley C, Munro Cullum C, Choy H, Ahn C, Timmerman R Neuro-oncology 2020 Dec 22 1831-1839 -
Margin-Free Fractionated Stereotactic Radiation Therapy for Pediatric Brain Tumors
Mohamad O, Wardak Z, Bowers DC, Le AH, Dan T, Abdulrahman R, Gargan L, Klesse L, Weprin B, Swift D, Price A, Ding C, Stojadinovic S, Sklar F, Braga B, Timmerman R Practical Radiation Oncology 2020 Nov 10 e485-e494 -
A web-based brain metastases segmentation and labeling platform for stereotactic radiosurgery
Yang Z, Liu H, Liu Y, Stojadinovic S, Timmerman R, Nedzi LA, Dan T, Wardak Z, Lu W, Gu X Medical physics 2020 Aug 47 3263-3276 -
Radiation Therapy for Pediatric Brain Tumors using Robotic Radiation Delivery System and Intensity Modulated Proton Therapy
Lin MH, Yang M, Dougherty J, Tasson A, Zhang Y, Mohamad O, Dan T, Yan Y, Gu X, Timmerman R, Laack N, Beltran C Practical Radiation Oncology 2020 May 10 e173-e182 -
Prolonged steroid dependence in adult patients with glioma
Mantilla EC, Abramowitz J, Dan T, Pan E Anticancer Research 2020 Apr 40 2059-2064 -
Considerations of target surface area and the risk of radiosurgical toxicity
Stojadinovic S, Yan Y, Leiker A, Ahn C, Wardak Z, Dan T, Nedzi LA, Timmerman R, Patel T, Barnett S, Mickey B, Meyer JJ PloS one 2019 Oct 14 -
MicroRNA-21 is Required for Hematopoietic Cell Viability After Radiation Exposure
Puccetti MV, Adams CM, Dan TD, Palagani A, Simone BA, DeAngelis T, Eischen CM, Simone NL International Journal of Radiation Oncology Biology Physics 2019 Aug 104 1165-1174 -
A recursive ensemble organ segmentation (REOS) framework: Application in brain radiotherapy
Chen H, Lu W, Chen M, Zhou L, Timmerman R, Tu D, Nedzi L, Wardak Z, Jiang S, Zhen X, Gu X Physics in medicine and biology 2019 Jan 64 -
Neoadjuvant Stereotactic Radiosurgery Before Surgical Resection of Cerebral Metastases
Patel AR, Nedzi L, Lau S, Barnett SL, Mickey BE, Moore W, Bindal S, Wardak Z, Dan T, Timmerman R, Patel TR World neurosurgery 2018 Dec 120 e480-e487 -
Bevacizumab and re-irradiation for recurrent high grade gliomas: does sequence matter?
Palmer JD, Bhamidipati D, Song A, Eldredge-Hindy HB, Siglin J, Dan TD, Champ CE, Zhang I, Bar-Ad V, Kim L, Glass J, Evans JJ, Andrews DW, Werner-Wasik M, Shi W Journal of Neuro-Oncology 2018 Dec 140 623-628 -
Caloric restriction counteracts chemotherapy-induced inflammation and increases response to therapy in a triple negative breast cancer model
Simone BA, Palagani A, Strickland K, Ko K, Jin L, Lim MK, Dan TD, Sarich M, Monti DA, Cristofanilli M, Simone NL Cell Cycle 2018 Jul 17 1536-1544 -
Correction to: Salvage fractionated stereotactic re-irradiation (FSRT) for patients with recurrent high grade gliomas progressed after bevacizumab treatment (Journal of Neuro-Oncology, (2018), 137, 1, (171-177), 10.1007/s11060-017-2709-0)
Shi W, Blomain ES, Siglin J, Palmer JD, Dan T, Wang Y, Werner-Wasik M, Glass J, Kim L, Bar Ad V, Bhamidipati D, Evans JJ, Judy K, Farrell CJ, Andrews DW Journal of Neuro-Oncology 2018 Mar 137 179 -
Salvage fractionated stereotactic re-irradiation (FSRT) for patients with recurrent high grade gliomas progressed after bevacizumab treatment
Shi W, Blomain ES, Siglin J, Palmer JJ, Dan T, Wang Y, Werner-Wasik M, Glass J, Kim L, Bar Ad V, Bhamidipati D, Evans JJ, Judy K, Farrell CJ, Andrews DW Journal of Neuro-Oncology 2018 Mar 137 171-177 -
The Influence of Health Insurance Policy on Radiation Oncology Physician SBRT/SABR Use Practices: A North American Survey
Guo J, Kim H, Kalchman I, Dan TD, Zhan T, Werner-Wasik M International Journal of Radiation Oncology Biology Physics 2017 Nov 99 524-529 -
The role of genomic techniques in predicting response to radiation therapy
Williams NL, Dan T, Zaorsky NG, Garg S, Den RB ONCOLOGY (United States) 2017 Jul 31 1-11 -
The Role of Genomic Techniques in Predicting Response to Radiation Therapy
Williams NL, Dan T, Zaorsky NG, Garg S, Den RB Oncology (Williston Park, N.Y.) 2017 Jul 31 562-570 -
Management of Stage I Lung Cancer with Stereotactic Ablative Radiation Therapy
Dan T, Williams NL Surgical Oncology Clinics of North America 2017 Jul 26 393-403 -
Hematologic Toxicity of Concurrent Administration of Radium-223 and Next-generation Antiandrogen Therapies
Dan TD, Eldredge-Hindy HB, Hoffman-Censits J, Lin J, Kelly WK, Gomella LG, Lallas CD, Trabulsi EJ, Hurwitz MD, Dicker AP, Den RB American Journal of Clinical Oncology: Cancer Clinical Trials 2017 40 342-347 -
Radioisotopes in management of metastatic prostate cancer
Raval A, Dan TD, Williams NL, Pridjian A, Den RB Indian Journal of Urology 2016 Oct 32 277-281 -
Caloric restriction coupled with radiation decreases metastatic burden in triple negative breast cancer
Simone BA, Dan T, Palagani A, Jin L, Han SY, Wright C, Savage JE, Gitman R, Lim MK, Palazzo J, Mehta MP, Simone NL Cell Cycle 2016 Sep 15 2265-2274 -
Quality and reporting accuracy of phase 1 drug radiation clinical trials
Kim H, Dan TD, Palmer JD, Leiby BE, Lawrence YR, Dicker AP JAMA Oncology 2016 Mar 2 390-391 -
Dosing, administration, and safety of radium-223: How i do it
Dan TD, Doyle L, Raval AJ, Pridjian A, Gomella LG, Den RB Canadian Journal of Urology 2016 23 8301-8305 -
Radium-223 in metastatic castrate resistant prostate cancer
Dan T, Williams N, Den RB 2016 Jan 171-185 -
Re-resection for recurrent high-grade glioma in the setting of re-irradiation: more is not always better
Palmer JD, Siglin J, Yamoah K, Dan T, Champ CE, Bar-Ad V, Werner-Wasik M, Evans JJ, Kim L, Glass J, Farrell C, Andrews DW, Shi W Journal of Neuro-Oncology 2015 Sep 124 215-221 -
Targeted drug combinations: Avant-garde oncology
Dan TD, Palmer JD Annals of Translational Medicine 2015 Jul 3 -
Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: Updated results of an institutional clinical management approach
Dan TD, Raben D, Schneider CJ, Hockstein NG, Witt RL, Dzeda M, Cormier JF, Raben A Oral Oncology 2015 Jun 51 616-621 -
Not so fast: Dietary restriction improves chemotherapy-related toxicity
Dan TD, Simone NL Cell Cycle 2015 Jan 14 2554-2555 -
What benefits could caloric restriction bring to cancer patients?
Dan TD, Wright CM, Simone NL Future Oncology 2014 Dec 10 2543-2546 -
MicroRNA alterations driving acute and late stages of radiation-induced fibrosis in a murine skin model
Simone BA, Ly D, Savage JE, Hewitt SM, Dan TD, Ylaya K, Shankavaram U, Lim M, Jin L, Camphausen K, Mitchell JB, Simone NL International Journal of Radiation Oncology Biology Physics 2014 Sep 90 44-52 -
MicroRNAs: The short link between cancer and RT-induced DNA damage response
Wright CM, Dan T, Dicker AP, Simone NL Frontiers in Oncology 2014 4 JUN -
CD44 is prognostic for overall survival in the NCI randomized trial on breast conservation with 25 year follow-up
Dan T, Hewitt SM, Ohri N, Ly D, Soule BP, Smith SL, Matsuda K, Council C, Shankavaram U, Lippman ME, Mitchell JB, Camphausen K, Simone NL Breast Cancer Research and Treatment 2014 Jan 143 11-18 -
Absence of bone marrow toxicity in elderly patients treated with recombinant human thyroid-stimulating hormone and empirically dosed radioiodine for thyroid cancer
Amdur RJ, Dan T, Mazzaferri E American Journal of Clinical Oncology: Cancer Clinical Trials 2013 Aug 36 348-353 -
Caloric restriction augments radiation efficacy in breast cancer
Saleh AD, Simone BA, Palazzo J, Savage JE, Sano Y, Dan T, Jin L, Champ C, Zhao S, Lim M, Sotgia F, Camphausen K, Pestell RG, Mitchell JB, Lisanti MP, Simone NL Cell Cycle 2013 Jun 12 1955-1963 -
Twenty-five year results of the national cancer institute randomized breast conservation trial
Simone NL, Dan T, Shih J, Smith SL, Sciuto L, Lita E, Lippman ME, Glatstein E, Swain SM, Danforth DN, Camphausen K Breast Cancer Research and Treatment 2012 Feb 132 197-203 -
Comparison of intensity-modulated radiotherapy, adaptive radiotherapy, proton radiotherapy, and adaptive proton radiotherapy for treatment of locally advanced head and neck cancer
Simone CB, Ly D, Dan TD, Ondos J, Ning H, Belard A, O'Connell J, Miller RW, Simone NL Radiotherapy and Oncology 2011 Dec 101 376-382 -
Emerging drugs to replace current leaders in first-line therapy for breast cancer
Cox MC, Dan TD, Swain SM Expert Opinion on Emerging Drugs 2006 Sep 11 489-501
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Where Does Auto-Segmentation for Brain Metastases Radiosurgery Stand Today?
Research
- Dr. Dan is a post-doc in the Mendell Lab, which focuses on mechanisms of post-transcriptional regulation of gene expression and how these pathways influence normal physiology and disease.
Clinical Focus
- Radiation Therapy for Cancer
- Radiation Therapy for Spinal Cord Cancer
- Acoustic Neuromas
- Bone Marrow Transplant
- Brain Metastases
- Pediatric Brain Tumors
- Brain & Spinal Cord Cancer
- Gliomas
- Meningiomas
- Pituitary Tumors
- Skull Base Tumors
- Radiation Therapy for Brain Tumors
Links
Results: 1 Locations
University Hospital Radiation Oncology Clinic
at Radiation Oncology Building 2280 Inwood RoadDallas, Texas 75390 214-645-8525 Directions to University Hospital Radiation Oncology Clinic
New Patient Appointment Accepting Virtual Visits or 214-645-8525