Much of the future of cancer care is in our genes. More than 1 million people in the United States are born with an underlying genetic mutation in all of their normal cells that predisposes them to cancer. Identifying these high-risk individuals is paramount to cancer prevention. For all patients, understanding the molecular mutations that lead to cancer will enable clinicians to improve cancer care. UT Southwestern has one of the premier Clinical Cancer Genetics programs in the country and the largest in North Texas. It is the only program in Dallas that offers a clinical service that is linked to a strong academic research program. The Harold C. Simmons Comprehensive Cancer Center genetics team is working to help our patients and clinicians put together hereditary pieces of the cancer puzzle.